BRENDA - Enzyme Database

Dinucleosidetetraphosphatase from Ehrlich ascites tumour cells: inhibition by adenosine, guanosine and uridine 5-tetraphosphates

Moreno, A.; Lobaton, C.D.; Sillero, M.A.G.; Sillero, A.; Int. J. Biochem. 14, 629-634 (1982)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.17
adenosine 5'-tetraphosphate
Ki in nanomolar range
Mus musculus
3.6.1.17
ADP
-
Mus musculus
3.6.1.17
AMP
-
Mus musculus
3.6.1.17
ATP
-
Mus musculus
3.6.1.17
GDP
-
Mus musculus
3.6.1.17
GMP
-
Mus musculus
3.6.1.17
GTP
-
Mus musculus
3.6.1.17
guanosine 5'-tetraphosphate
Ki in nanomolar range
Mus musculus
3.6.1.17
UDP
-
Mus musculus
3.6.1.17
uridine 5'-tetraphosphate
Ki in nanomolar range
Mus musculus
3.6.1.17
UTP
-
Mus musculus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.6.1.17
Mg2+
required, maximum activity at 1 mM
Mus musculus
3.6.1.17
Mn2+
required, maximum activity at 0.5 mM
Mus musculus
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.6.1.17
19800
-
gel filtration
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Mus musculus
-
ATP + AMP
-
Mus musculus
?
3.6.1.17
P1,P4-bis(5'-guanosyl)tetraphosphate + H2O
Mus musculus
-
GTP + GMP
-
Mus musculus
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.6.1.17
Mus musculus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.6.1.17
partial
Mus musculus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.6.1.17
Ehrlich ascites carcinoma cell
-
Mus musculus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.6.1.17
0.0074
-
crude exctract
Mus musculus
3.6.1.17
0.276
-
partially purified enzyme
Mus musculus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209897
Mus musculus
ATP + AMP
-
209897
Mus musculus
?
3.6.1.17
P1,P4-bis(5'-guanosyl)tetraphosphate + H2O
-
209897
Mus musculus
GTP + GMP
-
209897
Mus musculus
?
3.6.1.17
P1,P4-bis(5'-xanthosyl) tetraphosphate + H2O
-
209897
Mus musculus
XTP + XMP
-
209897
Mus musculus
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.17
adenosine 5'-tetraphosphate
Ki in nanomolar range
Mus musculus
3.6.1.17
ADP
-
Mus musculus
3.6.1.17
AMP
-
Mus musculus
3.6.1.17
ATP
-
Mus musculus
3.6.1.17
GDP
-
Mus musculus
3.6.1.17
GMP
-
Mus musculus
3.6.1.17
GTP
-
Mus musculus
3.6.1.17
guanosine 5'-tetraphosphate
Ki in nanomolar range
Mus musculus
3.6.1.17
UDP
-
Mus musculus
3.6.1.17
uridine 5'-tetraphosphate
Ki in nanomolar range
Mus musculus
3.6.1.17
UTP
-
Mus musculus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.6.1.17
Mg2+
required, maximum activity at 1 mM
Mus musculus
3.6.1.17
Mn2+
required, maximum activity at 0.5 mM
Mus musculus
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.6.1.17
19800
-
gel filtration
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Mus musculus
-
ATP + AMP
-
Mus musculus
?
3.6.1.17
P1,P4-bis(5'-guanosyl)tetraphosphate + H2O
Mus musculus
-
GTP + GMP
-
Mus musculus
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.6.1.17
partial
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.6.1.17
Ehrlich ascites carcinoma cell
-
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.6.1.17
0.0074
-
crude exctract
Mus musculus
3.6.1.17
0.276
-
partially purified enzyme
Mus musculus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209897
Mus musculus
ATP + AMP
-
209897
Mus musculus
?
3.6.1.17
P1,P4-bis(5'-guanosyl)tetraphosphate + H2O
-
209897
Mus musculus
GTP + GMP
-
209897
Mus musculus
?
3.6.1.17
P1,P4-bis(5'-xanthosyl) tetraphosphate + H2O
-
209897
Mus musculus
XTP + XMP
-
209897
Mus musculus
?