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Literature summary extracted from

  • Jaffe, J.J.; Chrin, L.R.; Smith, R.B.
    5,10-Methenyltetrahydrofolate cyclohydrolase and 5-formyltetrahydrofolate cyclodehydrase in Aedes aegypti (1980), Comp. Biochem. Physiol. B, 66, 597-600.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.9 Cu2+
-
 Aedes aegypti
3.5.4.9 Cu2+
-
 Bos taurus
3.5.4.9 Fe2+
-
 Aedes aegypti
3.5.4.9 Fe2+
-
 Bos taurus
3.5.4.9 Mg2+
-
 Aedes aegypti
3.5.4.9 Mg2+
-
 Bos taurus
3.5.4.9 p-chloromercuribenzoate
-
 Aedes aegypti
3.5.4.9 suramin
-
 Aedes aegypti
3.5.4.9 Zn2+
-
 Aedes aegypti
3.5.4.9 Zn2+
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.9 0.07
-
 10-formyltetrahydrofolate
-
 Sus scrofa
3.5.4.9 0.07
-
 10-formyltetrahydrofolate
-
 Aedes aegypti
3.5.4.9 0.09
-
 5,10-methenyltetrahydrofolate
-
 Aedes aegypti
3.5.4.9 0.1
-
 10-formyltetrahydrofolate
-
 Bos taurus
3.5.4.9 0.25
-
 5,10-methenyltetrahydrofolate
-
 Bos taurus
3.5.4.9 0.25
-
 5,10-methenyltetrahydrofolate
-
 Ovis aries
3.5.4.9 0.47
-
 10-formyltetrahydrofolate
-
 Ovis aries

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.9 200000
-
 gel filtration Aedes aegypti
3.5.4.9 218000
-
 isoenzyme Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.9 10-formyltetrahydrofolate Sus scrofa
-
 5,10-methenyltetrahydrofolate + H2O
-
 r
3.5.4.9 10-formyltetrahydrofolate Bos taurus
-
 5,10-methenyltetrahydrofolate + H2O
-
 r
3.5.4.9 10-formyltetrahydrofolate Oryctolagus cuniculus
-
 5,10-methenyltetrahydrofolate + H2O
-
 r
3.5.4.9 10-formyltetrahydrofolate Aedes aegypti
-
 5,10-methenyltetrahydrofolate + H2O
-
 r
3.5.4.9 10-formyltetrahydrofolate Aedes aegypti black-eye
-
 5,10-methenyltetrahydrofolate + H2O
-
 r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O Sus scrofa
-
 10-formyltetrahydrofolate
-
 r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O Bos taurus
-
 10-formyltetrahydrofolate
-
 r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O Oryctolagus cuniculus
-
 10-formyltetrahydrofolate
-
 r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O Ovis aries
-
 10-formyltetrahydrofolate
-
 ?
3.5.4.9 5,10-methenyltetrahydrofolate + H2O Aedes aegypti
-
 10-formyltetrahydrofolate
-
 r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O Aedes aegypti black-eye
-
 10-formyltetrahydrofolate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.9 Aedes aegypti
-
 mosquito, Liverpool black-eye strain
-
3.5.4.9 Aedes aegypti black-eye
-
 mosquito, Liverpool black-eye strain
-
3.5.4.9 Bos taurus
-
 beef
-
3.5.4.9 Oryctolagus cuniculus
-
 rabbit
-
3.5.4.9 Ovis aries
-
 sheep, trifunctional enzyme
-
3.5.4.9 Sus scrofa
-
 pig, trifunctional enzyme
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.9 liver
-
 Sus scrofa
-
3.5.4.9 liver
-
 Bos taurus
-
3.5.4.9 liver
-
 Oryctolagus cuniculus
-
3.5.4.9 liver
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.9 10-formyltetrahydrofolate
-
 Sus scrofa 5,10-methenyltetrahydrofolate + H2O
-
 r
3.5.4.9 10-formyltetrahydrofolate
-
 Bos taurus 5,10-methenyltetrahydrofolate + H2O
-
 r
3.5.4.9 10-formyltetrahydrofolate
-
 Oryctolagus cuniculus 5,10-methenyltetrahydrofolate + H2O
-
 r
3.5.4.9 10-formyltetrahydrofolate
-
 Aedes aegypti 5,10-methenyltetrahydrofolate + H2O
-
 r
3.5.4.9 10-formyltetrahydrofolate
-
 Aedes aegypti black-eye 5,10-methenyltetrahydrofolate + H2O
-
 r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O
-
 Sus scrofa 10-formyltetrahydrofolate
-
 r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O
-
 Bos taurus 10-formyltetrahydrofolate
-
 r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O
-
 Oryctolagus cuniculus 10-formyltetrahydrofolate
-
 r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O
-
 Ovis aries 10-formyltetrahydrofolate
-
 ?
3.5.4.9 5,10-methenyltetrahydrofolate + H2O
-
 Aedes aegypti 10-formyltetrahydrofolate
-
 r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O
-
 Aedes aegypti black-eye 10-formyltetrahydrofolate
-
 r

Synonyms

EC Number Synonyms Comment Organism
3.5.4.9 CHF4CH
-
 Aedes aegypti
3.5.4.9 mosquito cyclohydrolase
-
 Aedes aegypti

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.9 6.5
-
-
 Aedes aegypti