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Literature summary extracted from
- Inhibition of cytidine deaminase by derivatives of 1-(beta-D-ribofuranosyl)-dihydropyrimidin-2-one(zebularine) (1992), Nucleosides Nucleotides, 11, 1781-1793.
No PubMed abstract available
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.5.4.5 | medicine | enzyme limits the effectiveness of the antineoplastic agent cytosine arabinoside or aracytidine in the treatment of acute myeloblastic leukemias, chemotherapeutic use of the inhibitor THU to protect antileukemic agents from deaminase attack, inhibitors of cytidine deaminase prolongs the plasma halflife of antitumor or antiviral drugs | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.4.5 | 1-(beta-D-ribofuranosyl)-dihydropyrimidine-2-one | zebularine | Homo sapiens |  |
| 3.5.4.5 | 2'-deoxyzebularine 5'-monophosphate | - |
Homo sapiens | |
| 3.5.4.5 | 3,4,5,6-Tetrahydrouridine | - |
Homo sapiens | |
| 3.5.4.5 | 3,4,5,6-Tetrahydrouridine | - |
Mus musculus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.4.5 | 0.05 | - |
cytidine | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.5 | cytidine + H2O | Mus musculus | - |
uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | Homo sapiens | - |
uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | Mus musculus BALB/c | - |
uridine + NH3 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.4.5 | Homo sapiens | - |
human | - |
| 3.5.4.5 | Mus musculus | - |
mouse | - |
| 3.5.4.5 | Mus musculus | - |
BALB/c | - |
| 3.5.4.5 | Mus musculus BALB/c | - |
BALB/c | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.4.5 | kidney | - |
Mus musculus | - |
| 3.5.4.5 | kidney | - |
Homo sapiens | - |
| 3.5.4.5 | liver | - |
Mus musculus | - |
| 3.5.4.5 | liver | - |
Homo sapiens | - |
| 3.5.4.5 | spleen | - |
Mus musculus | - |
| 3.5.4.5 | spleen | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.5 | cytidine + H2O | - |
Mus musculus | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Homo sapiens | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Mus musculus BALB/c | uridine + NH3 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.4.5 | CDA | - |
Homo sapiens |
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