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Literature summary extracted from

  • Fanucchi, M.P.; Watanabe, K.A.; Fox, J.J.; Chou, T.
    Kinetics and substrate specificity of human and canine cytidine deaminase (1986), Biochem. Pharmacol., 35, 1199-1201.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.5 3,4,5,6-Tetrahydrouridine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.5 0.049
-
 cytidine
-
 Homo sapiens
3.5.4.5 0.055
-
 deoxycytidine
-
 Homo sapiens
3.5.4.5 0.27
-
 1-beta-D-arabinofuranosylcytosine
-
 Homo sapiens
3.5.4.5 0.31
-
 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine leukemia enzyme Homo sapiens
3.5.4.5 0.33
-
 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine
-
 Homo sapiens
3.5.4.5 0.51
-
 1-beta-D-arabinofuranosylcytosine
-
 Canis lupus familiaris
3.5.4.5 0.66
-
 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine
-
 Canis lupus familiaris
3.5.4.5 2.8
-
 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine
-
 Homo sapiens
3.5.4.5 3.9
-
 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine
-
 Canis lupus familiaris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.5 cytidine + H2O Homo sapiens
-
 uridine + NH3
-
 ?
3.5.4.5 cytidine + H2O Canis lupus familiaris
-
 uridine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.5 Canis lupus familiaris
-
 dog
-
3.5.4.5 Homo sapiens
-
 human
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.5 liver
-
 Homo sapiens
-
3.5.4.5 liver
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.5 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
-
 Homo sapiens ?
-
 ?
3.5.4.5 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O FIAC poorly deminated Canis lupus familiaris ?
-
 ?
3.5.4.5 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine + H2O
-
 Homo sapiens ?
-
 ?
3.5.4.5 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine + H2O
-
 Canis lupus familiaris ?
-
 ?
3.5.4.5 1-beta-D-arabinofuranosylcytosine + H2O
-
 Homo sapiens ?
-
 ?
3.5.4.5 1-beta-D-arabinofuranosylcytosine + H2O
-
 Canis lupus familiaris ?
-
 ?
3.5.4.5 cytidine + H2O
-
 Homo sapiens uridine + NH3
-
 ?
3.5.4.5 cytidine + H2O
-
 Canis lupus familiaris uridine + NH3
-
 ?
3.5.4.5 deoxycytidine + H2O
-
 Homo sapiens deoxyuridine + NH3
-
 ?
3.5.4.5 deoxycytidine + H2O
-
 Canis lupus familiaris deoxyuridine + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.5 canine hepatic cyd deaminase
-
 Canis lupus familiaris
3.5.4.5 cyd deaminase
-
 Homo sapiens
3.5.4.5 cyd deaminase
-
 Canis lupus familiaris