show Kinetics and substrate specificity of human and canine cytidine deaminase
Fanucchi, M.P.; Watanabe, K.A.; Fox, J.J.; Chou, T.; Biochem. Pharmacol. 35, 1199-1201 (1986)
Data extracted from this reference:
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.5
3,4,5,6-Tetrahydrouridine
-
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.5.4.5
0.049
-
cytidine
-
Homo sapiens
3.5.4.5
0.055
-
deoxycytidine
-
Homo sapiens
3.5.4.5
0.27
-
1-beta-D-arabinofuranosylcytosine
-
Homo sapiens
3.5.4.5
0.31
-
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine
leukemia enzyme
Homo sapiens
3.5.4.5
0.33
-
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine
-
Homo sapiens
3.5.4.5
0.51
-
1-beta-D-arabinofuranosylcytosine
-
Canis lupus familiaris
3.5.4.5
0.66
-
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine
-
Canis lupus familiaris
3.5.4.5
2.8
-
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine
-
Homo sapiens
3.5.4.5
3.9
-
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine
-
Canis lupus familiaris
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.5
cytidine + H2O
Homo sapiens
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Canis lupus familiaris
-
uridine + NH3
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.4.5
Canis lupus familiaris
-
dog
-
3.5.4.5
Homo sapiens
-
human
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.4.5
liver
-
Canis lupus familiaris
-
3.5.4.5
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
-
209657
Homo sapiens
?
-
-
-
?
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
FIAC poorly deminated
209657
Canis lupus familiaris
?
-
-
-
?
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine + H2O
-
209657
Homo sapiens
?
-
-
-
?
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine + H2O
-
209657
Canis lupus familiaris
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209657
Homo sapiens
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209657
Canis lupus familiaris
?
-
-
-
?
3.5.4.5
cytidine + H2O
-
209657
Homo sapiens
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209657
Canis lupus familiaris
uridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209657
Homo sapiens
deoxyuridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209657
Canis lupus familiaris
deoxyuridine + NH3
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.5
3,4,5,6-Tetrahydrouridine
-
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.5.4.5
0.049
-
cytidine
-
Homo sapiens
3.5.4.5
0.055
-
deoxycytidine
-
Homo sapiens
3.5.4.5
0.27
-
1-beta-D-arabinofuranosylcytosine
-
Homo sapiens
3.5.4.5
0.31
-
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine
leukemia enzyme
Homo sapiens
3.5.4.5
0.33
-
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine
-
Homo sapiens
3.5.4.5
0.51
-
1-beta-D-arabinofuranosylcytosine
-
Canis lupus familiaris
3.5.4.5
0.66
-
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine
-
Canis lupus familiaris
3.5.4.5
2.8
-
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine
-
Homo sapiens
3.5.4.5
3.9
-
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine
-
Canis lupus familiaris
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.5
cytidine + H2O
Homo sapiens
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Canis lupus familiaris
-
uridine + NH3
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.4.5
liver
-
Canis lupus familiaris
-
3.5.4.5
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
-
209657
Homo sapiens
?
-
-
-
?
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
FIAC poorly deminated
209657
Canis lupus familiaris
?
-
-
-
?
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine + H2O
-
209657
Homo sapiens
?
-
-
-
?
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine + H2O
-
209657
Canis lupus familiaris
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209657
Homo sapiens
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209657
Canis lupus familiaris
?
-
-
-
?
3.5.4.5
cytidine + H2O
-
209657
Homo sapiens
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209657
Canis lupus familiaris
uridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209657
Homo sapiens
deoxyuridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209657
Canis lupus familiaris
deoxyuridine + NH3
-
-
-
?