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Literature summary extracted from

  • Xie, L.; Smith, J.A.; Gross, S.S.
    GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine (1998), J. Biol. Chem., 273, 21091-21098.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.4.16 expression in Escherichia coli Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.16 2,4-Diamino-6-hydroxypyrimidine direct inhibitition at higher concentrations Rattus norvegicus
3.5.4.16 L-erythro-5,6,7,8-tetrahydrobiopterin indirect inhibition of 2,4-diamino-6-hydroxypyrimidine at lower concentrations with the help of feedback regulatory protein Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.16 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.16 expression in Escherichia coli Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.16 muscle aortic vascular, smooth Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.16 GTP + H2O
-
 Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?