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Literature summary extracted from

  • Grace, M.E.; Gregory, F.M.; Hung, P.P.; Fu, K.P.
    Purification and properties of a beta-lactamase from Proteus penneri (1986), J. Antibiot., 7, 938-942.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 clavulanic acid
-
 Proteus penneri
3.5.2.6 Sulbactam
-
 Proteus penneri

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.017
-
 benzylpenicillin
-
 Proteus penneri
3.5.2.6 0.071
-
 cephalothin
-
 Proteus penneri
3.5.2.6 0.079
-
 ampicillin
-
 Proteus penneri
3.5.2.6 0.114
-
 cefttriaxone
-
 Proteus penneri
3.5.2.6 0.328
-
 cefotaxime
-
 Proteus penneri
3.5.2.6 0.343
-
 cefuroxime
-
 Proteus penneri
3.5.2.6 0.368
-
 cephaloridine
-
 Proteus penneri

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.2.6 30000
-
 SDS-PAGE Proteus penneri

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Proteus penneri
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.2.6
-
 Proteus penneri

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 ampicillin + H2O 9% relative activity to cephaloridine Proteus penneri (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 benzylpenicillin + H2O 3% relative activity to cephaloridine Proteus penneri (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cefoperazone + H2O 11% relative activity to cephaloridine Proteus penneri (2R)-2-[(R)-carboxy{[(2S)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino}methyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefotaxime + H2O 48% relative activity to cephaloridine Proteus penneri (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 ceftriaxone + H2O 23% relative activity to cephaloridine Proteus penneri (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefuroxime + H2O 93% relative activity to cephaloridine Proteus penneri (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephaloridine + H2O 100% relative activity to other substrates tested Proteus penneri (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephalothin + H2O 50% relative activity to cephaloridine Proteus penneri (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.2.6 monomer 1* 30000 Proteus penneri

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.2.6 45
-
-
 Proteus penneri

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.2.6 6.5
-
-
 Proteus penneri