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Literature summary extracted from

  • Barash, V.; Flhor, D.; Morag, B.; Boneh, A.; Elpeleg, O.N.; Gilon, C.
    A radiometric assay for aspartoacylase activity in human fibroblasts: application for the diagnosis of canavan's disease (1991), Clin. Chim. Acta, 201, 175-182.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.15 medicine diagnosis of Canavan disease, an autosomal recessive neurodegenerative disorder characterized by aspartoacylase deficiency, technique for prenatal diagnosis Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.15 1.8 2 N-acyl-L-aspartic acid
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.15 cytosol
-
 Homo sapiens 5829
-
3.5.1.15 cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.15 N-acetyl-L-aspartic acid + H2O Homo sapiens
-
 acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O Rattus norvegicus
-
 acetate + aspartic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.15 Homo sapiens
-
 human
-
3.5.1.15 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.15 fibroblast
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
3.5.1.15 -70°C, kept for up to 4 weeks without loss of activity Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Homo sapiens acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Rattus norvegicus acetate + aspartic acid
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Homo sapiens acetate + L-aspartate
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Rattus norvegicus acetate + L-aspartate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.15 8.5
-
-
 Homo sapiens