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Literature summary extracted from

  • Hsu, L.L.; Paul, S.M.; Halaris, A.E.; Freedman, D.X.
    Rat brain aryl acylamidase: multiple forms and inhibition effects of LSD, serotonin and related compounds (1977), Life Sci., 20, 857-866.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.13 2-bromo-lysergic acid diethylamide marked inhibition of enzyme form AAA1 at pH 7.5, moderate inhibition of enzyme form AAA-1 at pH 5.5 Rattus norvegicus
3.5.1.13 d-lysergic acid diethylamide marked inhibition of enzyme form AAA1 at pH 7.5, moderate inhibition of enzyme form AAA-1 at pH 5.5 Rattus norvegicus
3.5.1.13 serotonin creatinine sulfate moderate inhibition of enzyme form AAA-1 at pH 7.5, no inhibition of enzyme form AAA-2 at pH 5.5 Rattus norvegicus
3.5.1.13 tryptamine slight inhibition of enzyme form AAA-1 at pH 7.5, no inhibition of enzyme form AAA-2 at pH 5.5 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.13 Rattus norvegicus
-
 enzyme form AAA-1 and AAA-2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.13 o-nitroacetanilide + H2O
-
 Rattus norvegicus 2-nitroaniline + acetate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.13 5.5
-
 enzyme form AAA-2 Rattus norvegicus
3.5.1.13 7.5
-
 enzyme form AAA-1 Rattus norvegicus