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Literature summary extracted from

  • Kanno, C.; Ohmura, Y.; Yanagisawa, H.
    Comparative study of the enzymatic properties of phosphodiesterases I from the plasma membrane of lactating bovine mammary gland and bovine milk fat globule membrane (1989), Agric. Biol. Chem., 53, 607-613.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.1 Co2+
-
 Bos taurus
3.1.4.1 Cu2+
-
 Bos taurus
3.1.4.1 EDTA
-
 Bos taurus
3.1.4.1 Mn2+
-
 Bos taurus
3.1.4.1 additional information no inhibition by anions Bos taurus
3.1.4.1 Ni2+
-
 Bos taurus
3.1.4.1 Zn2+
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.1 1.6
-
 p-nitrophenylthymidine 5'-phosphate milk fat globule membrane Bos taurus
3.1.4.1 1.7
-
 p-nitrophenylthymidine 5'-phosphate cytoplasmic membrane of mammary gland Bos taurus
3.1.4.1 8
-
 bis(p-nitrophenyl) phosphate milk fat globule membrane Bos taurus
3.1.4.1 14.4
-
 bis(p-nitrophenyl) phosphate cytoplasmic membrane of mammary gland Bos taurus
3.1.4.1 152.2
-
 p-Nitrophenyl phenylphosphonate cytoplasmic membrane of mammary gland Bos taurus
3.1.4.1 202
-
 p-Nitrophenyl phenylphosphonate milk fat globule membrane Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.1 cytoplasmic membrane mammary gland Bos taurus
-
-
3.1.4.1 lipid particle milk fat Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.1 Ca2+ slight activation Bos taurus
3.1.4.1 divalent cations required for activity Bos taurus
3.1.4.1 Mg2+ slight activation Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.1 additional information Bos taurus the enzyme may be important in nucleotide metabolism on the cell surface ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.1 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.1 partial, milk fat globule membrane Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.1 mammary gland
-
 Bos taurus
-
3.1.4.1 milk fat
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.1 additional information
-
-
 Bos taurus
3.1.4.1 0.03
-
 cytoplasmic membrane of mammary gland Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.1 bis(p-nitrophenyl) phosphate + H2O
-
 Bos taurus ?
-
 ?
3.1.4.1 additional information no activity with p-nitrophenylthymidine 3'-phosphate Bos taurus ?
-
 ?
3.1.4.1 additional information the enzyme may be important in nucleotide metabolism on the cell surface Bos taurus ?
-
 ?
3.1.4.1 p-nitrophenyl phenylphosphonate + H2O
-
 Bos taurus p-nitrophenol + benzenephosphonic acid
-
 ?
3.1.4.1 p-nitrophenylthymidine 5'-phosphate + H2O
-
 Bos taurus 5'-TMP + p-nitrophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.1 alkaline phosphodiesterase
-
 Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.1 9.5 9.6
-
 Bos taurus