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Literature summary extracted from

  • Tan, G.T.; Lee, S.; Lee, I.S.; Chen, J.; Leitner, P.; Besterman, J.; Kinghorn, A.D.; Pezzuto, J.M.
    Natural-product inhibitors of human DNA ligase I (1996), Biochem. J., 314, 993-1000.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.1 aleuritolic acid
-
 Homo sapiens
6.5.1.1 chelerythrine chloride
-
 Homo sapiens
6.5.1.1 Fagaronine chloride
-
 Homo sapiens
6.5.1.1 Fulvoplumierin
-
 Homo sapiens
6.5.1.1 morin
-
 Homo sapiens
6.5.1.1 myricetin
-
 Homo sapiens
6.5.1.1 Nitidine chloride
-
 Homo sapiens
6.5.1.1 oleanolic acid
-
 Homo sapiens
6.5.1.1 Protolichesterinic acid
-
 Homo sapiens
6.5.1.1 Sanguinarine nitrate
-
 Homo sapiens
6.5.1.1 Swertifrancheside
-
 Homo sapiens
6.5.1.1 ursolic acid
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens
-
 DNA ligase I
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
 ?