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Literature summary extracted from

  • Libor, S.M.; Sundaram, T.K.; Scrutton, M.C.
    Pyruvate carboxylase from a thermophilic Bacillus (1978), Biochem. J., 169, 543-558.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.4.1.1 acetyl-CoA
-
 Gallus gallus
6.4.1.1 acetyl-CoA activates Rattus norvegicus
6.4.1.1 acetyl-CoA activates Bacillus sp. (in: Bacteria)
6.4.1.1 acetyl-CoA best activator Bacillus sp. (in: Bacteria)
6.4.1.1 acetyl-CoA in absence of acetyl-CoA the maximal rate of oxaloacetate synthesis is 20% of that obtained in presence of saturating concentrations of acetyl-CoA Bacillus sp. (in: Bacteria)
6.4.1.1 acyl-CoA derivatives activate Bacillus sp. (in: Bacteria)
6.4.1.1 methanesulfonyl-CoA activates Saccharomyces cerevisiae
6.4.1.1 methanesulfonyl-CoA activates Bacillus sp. (in: Bacteria)
6.4.1.1 methanesulfonyl-CoA inhibition Gallus gallus
6.4.1.1 methanesulfonyl-CoA inhibition Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.1 2-oxoglutarate
-
 Gallus gallus
6.4.1.1 2-oxoglutarate
-
 Rattus norvegicus
6.4.1.1 methanesulfonyl-CoA activation Bacillus sp. (in: Bacteria)
6.4.1.1 methanesulfonyl-CoA
-
 Gallus gallus
6.4.1.1 methanesulfonyl-CoA
-
 Rattus norvegicus
6.4.1.1 methanesulfonyl-CoA activation Saccharomyces cerevisiae
6.4.1.1 Trinitrobenzenesulfonate inactivation of acetyl-CoA dependent activity, no effect on activator-independent activity Bacillus sp. (in: Bacteria)
6.4.1.1 Trinitrobenzenesulfonate
-
 Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.4.1.1 16
-
 HCO3- with saturating concentrations of the activator acetyl-CoA Bacillus sp. (in: Bacteria)
6.4.1.1 400
-
 HCO3- without acetyl-CoA Bacillus sp. (in: Bacteria)

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.1 Bacillus sp. (in: Bacteria)
-
 thermophilic
-
6.4.1.1 Gallus gallus
-
-
-
6.4.1.1 Rattus norvegicus
-
-
-
6.4.1.1 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.1 liver
-
 Gallus gallus
-
6.4.1.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.1 ATP + pyruvate + HCO3-
-
 Gallus gallus ADP + phosphate + oxaloacetate
-
 ?
6.4.1.1 ATP + pyruvate + HCO3-
-
 Rattus norvegicus ADP + phosphate + oxaloacetate
-
 ?
6.4.1.1 ATP + pyruvate + HCO3-
-
 Saccharomyces cerevisiae ADP + phosphate + oxaloacetate
-
 ?
6.4.1.1 ATP + pyruvate + HCO3-
-
 Bacillus sp. (in: Bacteria) ADP + phosphate + oxaloacetate
-
 ?