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Literature summary extracted from
- Regulation of N-carbamoyl-beta-alanine amidohydrolase, the terminal enzyme in pyrimidine catabolism, by ligand-induced change in polymerization (1987), J. Biol. Chem., 262, 7232-7237.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.6 | beta-Alanine | product inhibition | Rattus rattus |  |
| 3.5.1.6 | gamma-aminobutyrate | product analog, product inhibition | Rattus rattus | |
| 3.5.1.6 | N-Amidino-beta-alanine | - |
Rattus rattus | |
| 3.5.1.6 | N-Carbamoylglycine | - |
Rattus rattus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.1.6 | 0.0065 | - |
N-Carbamoyl-beta-alanine | pH 6.8 | Rattus rattus | |
| 3.5.1.6 | 0.0174 | - |
N-Carbamoyl-beta-alanine | pH 7.4 | Rattus rattus | |
| 3.5.1.6 | 0.032 | - |
N-Carbamoyl-beta-alanine | pH 8.1 | Rattus rattus | |
| 3.5.1.6 | 0.038 | - |
N-Carbamoyl-beta-alanine | - |
Euglena gracilis | |
| 3.5.1.6 | 0.634 | - |
N-Carbamoyl-beta-alanine | - |
Clostridium uracilicum | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.6 | 235000 | - |
gel filtration, native enzyme in absence of ligands | Rattus rattus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | Mus musculus | - |
? | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | Homo sapiens | - |
? | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | Euglena gracilis | - |
? | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | Rattus rattus | - |
? | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | Clostridium uracilicum | - |
? | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | Clostridium uracilicum M5-2 | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.6 | Clostridium uracilicum | - |
- |
- |
| 3.5.1.6 | Clostridium uracilicum M5-2 | - |
- |
- |
| 3.5.1.6 | Euglena gracilis | - |
plant-like unicellular flagellate | - |
| 3.5.1.6 | Homo sapiens | - |
human | - |
| 3.5.1.6 | Mus musculus | - |
mouse | - |
| 3.5.1.6 | Rattus rattus | - |
rat | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.6 | kidney | - |
Homo sapiens | - |
| 3.5.1.6 | kidney | - |
Rattus rattus | - |
| 3.5.1.6 | liver | - |
Mus musculus | - |
| 3.5.1.6 | liver | - |
Homo sapiens | - |
| 3.5.1.6 | liver | - |
Rattus rattus | - |
| 3.5.1.6 | lung | - |
Homo sapiens | - |
| 3.5.1.6 | lung | - |
Rattus rattus | - |
| 3.5.1.6 | pancreas | - |
Homo sapiens | - |
| 3.5.1.6 | pancreas | - |
Rattus rattus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | L enantiomer specific hydrolysis | Mus musculus | beta-alanine + CO2 + NH3 | - |
ir | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | L enantiomer specific hydrolysis | Homo sapiens | beta-alanine + CO2 + NH3 | - |
ir | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | L enantiomer specific hydrolysis | Euglena gracilis | beta-alanine + CO2 + NH3 | - |
ir | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | L enantiomer specific hydrolysis | Rattus rattus | beta-alanine + CO2 + NH3 | - |
ir | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | L enantiomer specific hydrolysis | Clostridium uracilicum | beta-alanine + CO2 + NH3 | - |
ir | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | L enantiomer specific hydrolysis | Clostridium uracilicum M5-2 | beta-alanine + CO2 + NH3 | - |
ir | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Mus musculus | ? | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Euglena gracilis | ? | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Rattus rattus | ? | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Clostridium uracilicum | ? | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Clostridium uracilicum M5-2 | ? | - |
? | |
| 3.5.1.6 | N-carbamoyl-DL-beta-aminoisobutyrate + H2O | - |
Euglena gracilis | DL-beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-DL-beta-aminoisobutyrate + H2O | - |
Rattus rattus | DL-beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.5.1.6 | polymer | 1500000-2000000, no subunit molecular weight reported | Euglena gracilis |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.6 | beta-alanine synthase | - |
Mus musculus |
| 3.5.1.6 | beta-alanine synthase | - |
Homo sapiens |
| 3.5.1.6 | beta-alanine synthase | - |
Euglena gracilis |
| 3.5.1.6 | beta-alanine synthase | - |
Rattus rattus |
| 3.5.1.6 | beta-alanine synthase | - |
Clostridium uracilicum |
| 3.5.1.6 | beta-ureidopropionate decarbamylase | - |
Mus musculus |
| 3.5.1.6 | beta-ureidopropionate decarbamylase | - |
Euglena gracilis |
| 3.5.1.6 | beta-ureidopropionate decarbamylase | - |
Rattus rattus |
| 3.5.1.6 | beta-ureidopropionate decarbamylase | - |
Clostridium uracilicum |
| 3.5.1.6 | NCbetaA | - |
Rattus rattus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.6 | 37 | - |
- |
Rattus rattus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.6 | 6.8 | - |
- |
Euglena gracilis |
| 3.5.1.6 | 6.8 | - |
- |
Rattus rattus |
| 3.5.1.6 | 7.5 | 8 | - |
Clostridium uracilicum |
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