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Literature summary extracted from

  • Rushton, A.R.; Dawson, G.
    Glycosphinoglipid beta-galactosidases of cultured mammalian cells. Characterization of the enzymes from mouse cell line lmtk and human Lesch-Nyhan fibroblasts (1975), Biochim. Biophys. Acta, 388, 92-105.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.46 taurocholate
-
 Mus musculus
3.2.1.46 taurocholate
-
 Homo sapiens
3.2.1.46 Triton X-100
-
 Mus musculus
3.2.1.46 Triton X-100
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.46 D-galactose
-
 Homo sapiens
3.2.1.46 D-galactose
-
 Mus musculus
3.2.1.46 lactose
-
 Homo sapiens
3.2.1.46 lactose
-
 Mus musculus
3.2.1.46 taurocholate high concentrations, above 0.3% w/v Homo sapiens
3.2.1.46 taurocholate high concentrations, above 0.3% w/v Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.2.1.46 Cl- activating Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.46 D-galactosyl-N-acylsphingosine + H2O Mus musculus
-
 ?
-
 ?
3.2.1.46 D-galactosyl-N-acylsphingosine + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.46 Homo sapiens
-
 Lesch-Nyhan cells
-
3.2.1.46 Mus musculus
-
 LMTK-cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.46 skin fibroblast Lesch-Nyhan cells Homo sapiens
-
3.2.1.46 skin fibroblast LMTK-cells Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.46 4-methylumbelliferyl beta-galactoside + H2O
-
 Mus musculus methylumbelliferone + beta-D-galactose
-
 ?
3.2.1.46 4-methylumbelliferyl beta-galactoside + H2O
-
 Homo sapiens methylumbelliferone + beta-D-galactose
-
 ?
3.2.1.46 D-galactosyl-N-acylsphingosine + H2O
-
 Mus musculus D-galactose + N-acylsphingosine
-
 ?
3.2.1.46 D-galactosyl-N-acylsphingosine + H2O
-
 Homo sapiens D-galactose + N-acylsphingosine
-
 ?
3.2.1.46 D-galactosyl-N-acylsphingosine + H2O
-
 Mus musculus ?
-
 ?
3.2.1.46 D-galactosyl-N-acylsphingosine + H2O
-
 Homo sapiens ?
-
 ?
3.2.1.46 galactocerebroside + H2O
-
 Mus musculus D-galactose + N-acylceramide
-
 ?
3.2.1.46 galactocerebroside + H2O
-
 Homo sapiens D-galactose + N-acylceramide
-
 ?
3.2.1.46 galactosylceramide + H2O
-
 Mus musculus D-galactose + N-acylceramide
-
 ?
3.2.1.46 galactosylceramide + H2O
-
 Homo sapiens D-galactose + N-acylceramide
-
 ?
3.2.1.46 GM1 ganglioside + H2O
-
 Mus musculus D-galactose + N-acylceramide
-
 ?
3.2.1.46 GM1 ganglioside + H2O
-
 Homo sapiens D-galactose + N-acylceramide
-
 ?
3.2.1.46 lactosylsphingosine + H2O
-
 Mus musculus lactose + sphingosine
-
 ?
3.2.1.46 lactosylsphingosine + H2O
-
 Homo sapiens lactose + sphingosine
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.2.1.46 54
-
 20 min, 45% inactivation Mus musculus
3.2.1.46 54
-
 10 min, 45% inactivation Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.46 4.1
-
-
 Mus musculus
3.2.1.46 4.4
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.2.1.46 3.5 5.3 pH 3.5: about 10% of maximal activity, pH 5.3: about 40% of maximal activity Mus musculus
3.2.1.46 3.5 5.3 pH 3.5: about 10% of maximal activity, pH 5.3: about 40% of maximal activity Homo sapiens