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Literature summary extracted from

  • Milman, H.A.; Cooney, D.A.
    Partial purification and properties of L-asparagine synthetase from mouse pancreas (1979), Biochem. J., 181, 51-59.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
6.3.5.4 activity is markedly decreased by freezing for 7 days at -87°C in the presence of 1 mM dithiothreitol. Protection by 10 mM dithiothreitol Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.4 2-Amino-4-arsonophenol hydrochloride
-
 Mus musculus
6.3.5.4 5-Chloro-4-oxo-L-norvaline
-
 Mus musculus
6.3.5.4 5-Diazo-4-oxo-L-norvaline
-
 Mus musculus
6.3.5.4 6-diazo-5-oxo-L-norleucine
-
 Mus musculus
6.3.5.4 aminomalonic acid competitive versus L-Asp Mus musculus
6.3.5.4 L-(alphaS,5S)-alpha-Amino-3-chloro-4,5-dihydroisoxazol-5-ylacetic acid i.e. NSC-163501 Mus musculus
6.3.5.4 L-Homoserine beta-adenylate in the presence of 30 mM MgCl2 Mus musculus
6.3.5.4 Maleimide
-
 Mus musculus
6.3.5.4 additional information mouse pancreas contains a proteolytic inhibitor of L-Asn synthetase Mus musculus
6.3.5.4 Mucochloric acid
-
 Mus musculus
6.3.5.4 Zn2+ ZnCl2 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.4 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.5.4 partial Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.5.4 pancreas
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.5.4 0.096
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.4 ATP + L-Asp + L-Gln ir Mus musculus AMP + diphosphate + Asn + Glu
-
 ?
6.3.5.4 additional information enzyme has inherent glutaminase activity Mus musculus ?
-
 ?