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Literature summary extracted from

  • Lee, T.C.; Uemura, Y.; Snyder, F.
    A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acetyl analogs of platelet-activating factor (PAF) with PAF as the actetate donor in HL-60 cells (1992), J. Biol. Chem., 267, 19992-20001.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.149 Mepacrine
-
 Homo sapiens
2.3.1.149 p-bromophenacyl bromide
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.149 0.012
-
 Hexadecyl-acetyl-sn-glycero-3-phosphocholine
-
 Homo sapiens
2.3.1.149 0.1064
-
 alk-1-enyllyso-sn-glycero-phosphoethanolamine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.149 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.149 additional information Homo sapiens the enzyme may participate in the biosynthesis of ethanolamine plasmalogen and acyl analogs of platelet-activating factor, in vivo, finetuning of platelet-activating factor biological responses and cross-talk between de novo and remodeling pathways of platelet biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.149 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.149 HL-60 cell
-
 Homo sapiens
-
2.3.1.149 pulmonary artery endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.149 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + acyllyso-sn-glycero-3-phosphate
-
 Homo sapiens ?
-
 ?
2.3.1.149 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + acyllyso-sn-glycero-3-phosphoinositol
-
 Homo sapiens ?
-
 ?
2.3.1.149 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + acyllyso-sn-glycero-3-phosphoserine
-
 Homo sapiens ?
-
 ?
2.3.1.149 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + alkyllyso-sn-glycero-3-phosphate
-
 Homo sapiens ?
-
 ?
2.3.1.149 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + cis-9-octadecen-1-ol
-
 Homo sapiens ?
-
 ?
2.3.1.149 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + lysoplasmalogen 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine is platelet-activating factor Homo sapiens 1-Alk-1-enyl-2-acetyl-sn-glycero-3-phosphoethanolamine + ?
-
 ?
2.3.1.149 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + radyllyso-sn-glycero-3-phosphocholine
-
 Homo sapiens ?
-
 ?
2.3.1.149 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + radyllyso-sn-glycero-3-phosphoethanolamine
-
 Homo sapiens ?
-
 ?
2.3.1.149 Hexadecyl-acetyl-sn-glycero-3-phosphocholine + alk-1-enyllyso-sn-glycero-phosphoethanolamine
-
 Homo sapiens ?
-
 ?
2.3.1.149 additional information the enzyme may participate in the biosynthesis of ethanolamine plasmalogen and acyl analogs of platelet-activating factor, in vivo, finetuning of platelet-activating factor biological responses and cross-talk between de novo and remodeling pathways of platelet biosynthesis Homo sapiens ?
-
 ?

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.3.1.149 15 24 active between 15°C and 24°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.149 7.4
-
-
 Homo sapiens