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Literature summary extracted from

  • Wright, H.T.; Nurse, K.C.; Goldstein, D.J.
    Naldixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases (1981), Science, 213, 455-456.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.4 Nalidixic acid
-
 Saccharomyces cerevisiae
6.1.1.4 novobiocin
-
 Saccharomyces cerevisiae
6.1.1.4 Oxolinic acid
-
 Saccharomyces cerevisiae
6.1.1.14 Nalidixic acid
-
 Saccharomyces cerevisiae
6.1.1.14 novobiocin
-
 Saccharomyces cerevisiae
6.1.1.14 Oxolinic acid
-
 Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.1.1.4 0.0003
-
 tRNALeu
-
 Saccharomyces cerevisiae
6.1.1.4 0.3
-
 ATP
-
 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.4 Saccharomyces cerevisiae
-
-
-
6.1.1.14 Escherichia coli
-
-
-
6.1.1.14 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.4 ATP + L-leucine + tRNALeu
-
 Saccharomyces cerevisiae AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.14 ATP + glycine + tRNAGly
-
 Escherichia coli AMP + diphosphate + glycyl-tRNAGly
-
 ?
6.1.1.14 ATP + glycine + tRNAGly
-
 Saccharomyces cerevisiae AMP + diphosphate + glycyl-tRNAGly
-
 ?