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Literature summary extracted from
- Adenosylhomocysteinase (bovine) (1987), Methods Enzymol., 143, 377-383.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 3.13.2.1 | - |
Bos taurus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.13.2.1 | (+/-)-aristeromycin | carbocyclic adenosine; competitive | Bos taurus |  |
| 3.13.2.1 | 2'-deoxyadenosine | irreversible | Bos taurus | |
| 3.13.2.1 | 2-aza-3-deazaadenosine | competitive | Bos taurus | |
| 3.13.2.1 | 2-chloro-3-deazaadenosine | irreversible | Bos taurus | |
| 3.13.2.1 | 2-chloroadenosine | irreversible | Bos taurus | |
| 3.13.2.1 | 3-deaza-(+/-)-aristeromycin | carbocyclic 3-deazaadenosine; competitive | Bos taurus | |
| 3.13.2.1 | 3-deazaadenosine | competitive | Bos taurus | |
| 3.13.2.1 | 7-deaza-8-azaadenosine | competitive; formycin A | Bos taurus | |
| 3.13.2.1 | 8-Aminoadenosine | competitive | Bos taurus | |
| 3.13.2.1 | 8-azaadenosine | competitive | Bos taurus | |
| 3.13.2.1 | 9-beta-D-arabinofuranosyl-2-chloroadenine | irreversible | Bos taurus | |
| 3.13.2.1 | 9-beta-D-arabinofuranosyl-2-fluoroadenine | irreversible | Bos taurus | |
| 3.13.2.1 | 9-beta-D-arabinofuranosyl-3-deazaadenine | irreversible | Bos taurus | |
| 3.13.2.1 | 9-beta-D-arabinofuranosyladenine | irreversible | Bos taurus | |
| 3.13.2.1 | adenosine N1-oxide | competitive | Bos taurus | |
| 3.13.2.1 | Inosine | competitive | Bos taurus | |
| 3.13.2.1 | N6-methyladenosine | competitive | Bos taurus | |
| 3.13.2.1 | nebularine | competitive | Bos taurus | |
| 3.13.2.1 | Nucleocidin | irreversible | Bos taurus | |
| 3.13.2.1 | Pyrazomycin | competitive | Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.13.2.1 | 0.0019 | - |
adenosine | - |
Bos taurus | |
| 3.13.2.1 | 0.15 | - |
L-homocysteine | - |
Bos taurus | |
| 3.13.2.1 | 2 | - |
Inosine | - |
Bos taurus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | Bos taurus | - |
adenosine + L-homocysteine | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | Bos taurus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.13.2.1 | glycoprotein | - |
Bos taurus |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.13.2.1 | - |
Bos taurus |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine | reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | 0.5 | 0.65 | - |
Bos taurus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.13.2.1 | -70°C, lyophilized, purified enzyme | Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | (+/-)-aristeromycin + homocysteine | carbocyclic adenosine | Bos taurus | ? | - |
r | |
| 3.13.2.1 | 2-aza-3-deazaadenosine + homocysteine | - |
Bos taurus | ? | - |
r | |
| 3.13.2.1 | 3-deaza-(+/-)-aristeromycin + homocysteine | carbocyclic 3-deazaadenosine | Bos taurus | ? | - |
r | |
| 3.13.2.1 | 3-deazaadenosine + L-homocysteine | - |
Bos taurus | 3-deazaadenosylhomocysteine | - |
r | |
| 3.13.2.1 | 7-deaza-8-azaadenosine + homocysteine | formycin A | Bos taurus | ? | - |
r | |
| 3.13.2.1 | 8-aminoadenosine + homocysteine | - |
Bos taurus | ? | - |
r | |
| 3.13.2.1 | 8-azaadenosine + homocysteine | - |
Bos taurus | ? | - |
r | |
| 3.13.2.1 | adenosine N1-oxide + homocysteine | - |
Bos taurus | ? | - |
r | |
| 3.13.2.1 | DL-homocysteine + adenosine | - |
Bos taurus | S-adenosyl-DL-homocysteine | - |
r | |
| 3.13.2.1 | inosine + homocysteine | - |
Bos taurus | ? | - |
r | |
| 3.13.2.1 | N6-methyladenosine + homocysteine | - |
Bos taurus | ? | - |
r | |
| 3.13.2.1 | nebularine + homocysteine | - |
Bos taurus | ? | - |
r | |
| 3.13.2.1 | pyrazomycin + homocysteine | - |
Bos taurus | ? | - |
r | |
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | - |
Bos taurus | adenosine + L-homocysteine | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.13.2.1 | tetramer | 4 * 5000 | Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.13.2.1 | NAD+ | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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