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Literature summary extracted from

  • Purohit, A.; Reed, M.J.; Morris, N.C.; Williams, G.J.; Potter, B.V.
    Regulation and inhibition of steroid sulfatase activity in breast cancer (1996), Ann. N. Y. Acad. Sci., 784, 40-49.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.6.2 interleukin-1 in cultured MCF-7 cells Homo sapiens
3.1.6.2 interleukin-1 inhibition of cell growth Homo sapiens
3.1.6.2 Tumor necrosis factor alpha in cultured MCF-7 cells Homo sapiens
3.1.6.2 Tumor necrosis factor alpha inhibition of cell growth Homo sapiens

Application

EC Number Application Comment Organism
3.1.6.2 medicine increased activity in endocrine-dependent tumors Homo sapiens
3.1.6.2 medicine higher activity in primary mammary carcinoma Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 breast cyst fluid
-
 Homo sapiens
3.1.6.2 estrone
-
 Homo sapiens
3.1.6.2 Estrone 3-sulfate
-
 Homo sapiens
3.1.6.2 estrone-3-O-(N,N-dimethyl)sulfamate
-
 Homo sapiens
3.1.6.2 estrone-3-O-(N-methyl)sulfamate
-
 Homo sapiens
3.1.6.2 estrone-3-O-methylthiophosphonate
-
 Homo sapiens
3.1.6.2 estrone-3-O-sulfamate EMATE, most potent, irreversible Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 steroid sulfates + H2O Homo sapiens also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.2 MCF-7 cell MCF-7 cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 estrone sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Homo sapiens steroid + sulfate
-
 ?