BRENDA - Enzyme Database show

Regulation and inhibition of steroid sulfatase activity in breast cancer

Purohit, A.; Reed, M.J.; Morris, N.C.; Williams, G.J.; Potter, B.V.; Ann. N. Y. Acad. Sci. 784, 40-49 (1996)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.6.2
interleukin-1
in cultured MCF-7 cells; inhibition of cell growth
Homo sapiens
3.1.6.2
Tumor necrosis factor alpha
in cultured MCF-7 cells; inhibition of cell growth
Homo sapiens
Application
EC Number
Application
Commentary
Organism
3.1.6.2
medicine
higher activity in primary mammary carcinoma; increased activity in endocrine-dependent tumors
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
breast cyst fluid
-
Homo sapiens
3.1.6.2
estrone
-
Homo sapiens
3.1.6.2
Estrone 3-sulfate
-
Homo sapiens
3.1.6.2
estrone-3-O-(N,N-dimethyl)sulfamate
-
Homo sapiens
3.1.6.2
estrone-3-O-(N-methyl)sulfamate
-
Homo sapiens
3.1.6.2
estrone-3-O-methylthiophosphonate
-
Homo sapiens
3.1.6.2
estrone-3-O-sulfamate
EMATE, most potent, irreversible
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
steroid sulfates + H2O
Homo sapiens
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
steroid + sulfate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.6.2
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.6.2
MCF-7 cell
MCF-7 cells
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
estrone sulfate + H2O
-
135619
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
steroid sulfates + H2O
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
135619
Homo sapiens
steroid + sulfate
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.6.2
interleukin-1
in cultured MCF-7 cells; inhibition of cell growth
Homo sapiens
3.1.6.2
Tumor necrosis factor alpha
in cultured MCF-7 cells; inhibition of cell growth
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
3.1.6.2
medicine
higher activity in primary mammary carcinoma; increased activity in endocrine-dependent tumors
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
breast cyst fluid
-
Homo sapiens
3.1.6.2
estrone
-
Homo sapiens
3.1.6.2
Estrone 3-sulfate
-
Homo sapiens
3.1.6.2
estrone-3-O-(N,N-dimethyl)sulfamate
-
Homo sapiens
3.1.6.2
estrone-3-O-(N-methyl)sulfamate
-
Homo sapiens
3.1.6.2
estrone-3-O-methylthiophosphonate
-
Homo sapiens
3.1.6.2
estrone-3-O-sulfamate
EMATE, most potent, irreversible
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
steroid sulfates + H2O
Homo sapiens
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
steroid + sulfate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.6.2
MCF-7 cell
MCF-7 cells
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
estrone sulfate + H2O
-
135619
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
steroid sulfates + H2O
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
135619
Homo sapiens
steroid + sulfate
-
-
-
?