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Literature summary extracted from

  • Corfield, A.P.; Rainey, J.B.; Clamp, J.R.; Wagner, S.A.
    Changes in the activity of the enzymes involved in sialic acid metabolism in isolated rat colonic mucosal cells on administration of azoxymethane (1983), Biochem. Soc. Trans., 11, 766-767.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.40 azoxymethane carcinogen, elevated enzyme activity in tumour cells Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.57 N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O Rattus norvegicus
-
 N-acetyl-neuraminate 9-phosphate + phosphate
-
 ?
2.5.1.57 N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O Rattus norvegicus Sprague-Dawley
-
 N-acetyl-neuraminate 9-phosphate + phosphate
-
 ?
2.7.1.60 ATP + N-acetyl-D-mannosamine Rattus norvegicus enzyme is involved in sialic acid metabolism ADP + N-acetyl-D-mannosamine 6-phosphate
-
 ?
2.7.1.60 ATP + N-acetyl-D-mannosamine Rattus norvegicus Sprague-Dawley enzyme is involved in sialic acid metabolism ADP + N-acetyl-D-mannosamine 6-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.57 Rattus norvegicus
-
 rat
-
2.5.1.57 Rattus norvegicus
-
 Sprague-Dawley
-
2.5.1.57 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-
2.7.1.60 Rattus norvegicus
-
 Sprague-Dawley
-
2.7.1.60 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-
3.1.4.40 Rattus norvegicus
-
 Sprague-Dawley
-
3.1.4.40 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-
5.1.3.8 Rattus norvegicus
-
-
-
5.1.3.14 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.57 colon
-
 Rattus norvegicus
-
2.5.1.57 colonic mucosa
-
 Rattus norvegicus
-
2.7.1.60 colonic mucosa normal mucosa, non-malignant mucosa, tumour Rattus norvegicus
-
3.1.4.40 colon
-
 Rattus norvegicus
-
3.1.4.40 intestinal mucosa
-
 Rattus norvegicus
-
5.1.3.8 intestinal mucosa normal, non-malignant. Low activity in tumour cells Rattus norvegicus
-
5.1.3.14 intestinal mucosa colonic mucosa: normal mucosa, non-malignant mucosa in azomethane treated animals, low activity in azomethane-induced tumor tissue Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.40 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.57 N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O
-
 Rattus norvegicus N-acetyl-neuraminate 9-phosphate + phosphate
-
 ?
2.5.1.57 N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O
-
 Rattus norvegicus Sprague-Dawley N-acetyl-neuraminate 9-phosphate + phosphate
-
 ?
2.7.1.60 ATP + N-acetyl-D-mannosamine enzyme is involved in sialic acid metabolism Rattus norvegicus ADP + N-acetyl-D-mannosamine 6-phosphate
-
 ?
2.7.1.60 ATP + N-acetyl-D-mannosamine enzyme is involved in sialic acid metabolism Rattus norvegicus Sprague-Dawley ADP + N-acetyl-D-mannosamine 6-phosphate
-
 ?
2.7.1.60 ATP + N-acetyl-D-mannosamine
-
 Rattus norvegicus ADP + N-acetyl-D-mannosamine-6-phosphate
-
 ?
2.7.1.60 ATP + N-acetyl-D-mannosamine
-
 Rattus norvegicus Sprague-Dawley ADP + N-acetyl-D-mannosamine-6-phosphate
-
 ?
5.1.3.8 N-Acyl-D-glucosamine
-
 Rattus norvegicus N-Acyl-D-mannosamine
-
 ?
5.1.3.8 N-Acyl-D-glucosamine
-
 Rattus norvegicus Sprague-Dawley N-Acyl-D-mannosamine
-
 ?