Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Methven, P.; Lemon, M.; Bhoola, K.
    The metabolism of cyclic nucleotides in the guinea-pig pancreas. Cyclic AMP phosphodiesterase and cyclic GMP phosphodiesterase (1980), Biochem. J., 186, 491-498.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
3.1.4.35 traysylol, protease inhibitor, stabilization Cavia porcellus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.35 3',5'-cAMP
-
 Cavia porcellus
3.1.4.35 3-isobutyl-1-methylxanthine
-
 Cavia porcellus
3.1.4.35 Ca2+ inhibitory at 1 mM together with Mg2+ below 0.1 mM Cavia porcellus
3.1.4.35 Caffeine
-
 Cavia porcellus
3.1.4.35 EDTA
-
 Cavia porcellus
3.1.4.35 Mg2+ inhibitory below 0.1 mM together with Ca2+ at 1 mM Cavia porcellus
3.1.4.35 papaverine
-
 Cavia porcellus
3.1.4.35 theophylline
-
 Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.35 0.00032
-
 3',5'-cGMP low affinity components Cavia porcellus
3.1.4.35 0.0319
-
 3',5'-cGMP high affinity components Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.35 cytosol subcelluar distribution Cavia porcellus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.35 Ca2+ activatory at 0.1-1 mM Cavia porcellus
3.1.4.35 Mg2+
-
 Cavia porcellus
3.1.4.35 Mn2+
-
 Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.35 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.35 pancreas
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.35 3',5'-cGMP + H2O
-
 Cavia porcellus 5'-GMP
-
 ?