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Literature summary extracted from

  • Grant, P.G.; Colman, R.W.
    Purification and characterization of a human platelet cyclic nucleotide phosphodiesterase (1984), Biochemistry, 23, 1801-1807.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 3-isobutyl-1-methylxanthine
-
 Homo sapiens
3.1.4.17 cAMP
-
 Homo sapiens
3.1.4.17 cGMP
-
 Homo sapiens
3.1.4.17 dipyridamole
-
 Homo sapiens
3.1.4.17 papaverine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.17 0.00002
-
 3',5'-cGMP
-
 Homo sapiens
3.1.4.17 0.00018
-
 3',5'-cAMP
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.17 Mg2+ required Homo sapiens
3.1.4.17 Mn2+ required Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.17 61000
-
 2 * 61000 Homo sapiens
3.1.4.17 140000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.17 2500-3000fold Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?
3.1.4.17 3',5'-cGMP + H2O
-
 Homo sapiens 5'-GMP
-
 ?
3.1.4.17 nucleoside 3',5'-cyclic phosphate + H2O
-
 Homo sapiens nucleoside 5'-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.17 dimer SDS-PAGE Homo sapiens
3.1.4.17 dimer 2 * 61000 Homo sapiens