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Literature summary extracted from

  • Wedgwood, J.F.; Strominger, J.L.
    Enzymatic activities in cultured human lymphocytes that dephosphorylate dolichyl pyrophosphate and dolichyl phosphate (1980), J. Biol. Chem., 255, 1120-1123.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.6.1.43 EDTA
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.51 phosphate
-
 Homo sapiens
3.6.1.43 bacitracin no inhibition when preincubating with EDTA Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.51 0.2
-
 dolichyl phosphate in presence of Triton X-100 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.51 plasma membrane
-
 Homo sapiens 5886
-
3.6.1.43 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.43 additional information no metal ions required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.43 dolichyl diphosphate + H2O Homo sapiens involved in biosynthesis of glycoproteins, regeneration of dolichyl phosphate dolichyl phosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.51 Homo sapiens
-
-
-
3.6.1.43 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.51 lymphocyte
-
 Homo sapiens
-
3.6.1.43 lymphocyte RPMI 4265 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.51 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.51 dolichyl phosphate + H2O
-
 Homo sapiens dolichol + phosphate
-
 ?
3.6.1.43 dolichyl diphosphate + H2O
-
 Homo sapiens dolichyl phosphate + phosphate
-
 ?
3.6.1.43 dolichyl diphosphate + H2O involved in biosynthesis of glycoproteins, regeneration of dolichyl phosphate Homo sapiens dolichyl phosphate + phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.51 6.5
-
-
 Homo sapiens
3.6.1.43 8
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.51 5 8 50% of maximal activity at pH 5 and at pH 8 Homo sapiens
3.6.1.43 7 9 95% and 90% of activity, broad pH-range Homo sapiens