Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kai, M.; Wada, I.; Imai, S.; Sakane, F.; Kanoh, H.
    Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase (1997), J. Biol. Chem., 272, 24572-24578.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.4 cloning of two Mg2+-independent isoenzymes, PAP-2a and PAP-2b Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 additional information post-Golgi localization Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.4 Mg2+ two Mg2+-independent isoenzymes: phosphatidic acid phosphatase PAP-1a and PAP-2b Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.4 32158
-
 x * 32158, isoenzyme PAP-2a, calculation from nucleotide sequence Homo sapiens
3.1.3.4 35119
-
 x * 35119, isoenzyme PAP-2b, calculation from nucleotide sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.4 additional information Homo sapiens critical roles of the enzyme in cell growth and differentiation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.4 glycoprotein the two Mg2+-independent isoenzymes, PAP-2a and PAP-2b are glycoproteins Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 brain
-
 Homo sapiens
-
3.1.3.4 colon
-
 Homo sapiens
-
3.1.3.4 heart
-
 Homo sapiens
-
3.1.3.4 kidney
-
 Homo sapiens
-
3.1.3.4 leukocyte peripheral blood Homo sapiens
-
3.1.3.4 additional information isoenzyme PAP-2b is almost ubiquitously in all human tissues, isoenzyme PAP-2a is undetectable in thymus, placenta and leukocytes Homo sapiens
-
3.1.3.4 ovary
-
 Homo sapiens
-
3.1.3.4 pancreas
-
 Homo sapiens
-
3.1.3.4 placenta
-
 Homo sapiens
-
3.1.3.4 prostate gland isoenzyme PAP2a Homo sapiens
-
3.1.3.4 skeletal muscle
-
 Homo sapiens
-
3.1.3.4 small intestine
-
 Homo sapiens
-
3.1.3.4 spleen
-
 Homo sapiens
-
3.1.3.4 testis
-
 Homo sapiens
-
3.1.3.4 thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 ceramide-1-phosphate + H2O isoenzyme PAP-2a and PAP-2b Homo sapiens ?
-
 ?
3.1.3.4 lysophosphatidate + H2O isoenzyme PAP-2a and PAP-2b Homo sapiens ?
-
 ?
3.1.3.4 additional information critical roles of the enzyme in cell growth and differentiation Homo sapiens ?
-
 ?
3.1.3.4 phosphatidic acid + H2O
-
 Homo sapiens 1,2-diacyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 sphingosine 1-phosphate + H2O hydrolysis by isoenzyme PAP-2b, no hydrolysis by isoenzyme PAP-2a Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.4 ? x * 32158, isoenzyme PAP-2a, calculation from nucleotide sequence Homo sapiens
3.1.3.4 ? x * 35119, isoenzyme PAP-2b, calculation from nucleotide sequence Homo sapiens