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Literature summary extracted from

  • Yeung, A.; Casola, P.G.; Wong, C.; Fellows, J.F.; Possmayer, F.
    Pulmonary phosphatidic acid phosphatase. A comparative study of the aqueously dispersed phosphatidate-dependent and membrane-bound phosphatidate-dependent phosphatidic acid phosphatase activities of rat lung (1979), Biochim. Biophys. Acta, 574, 226-239.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.4 Ca2+ activity with aqueously dispersed phosphatidic acid Rattus norvegicus
3.1.3.4 F- activity with aqueously dispersed phosphatidic acid Rattus norvegicus
3.1.3.4 Mg2+ at high concentrations, activity with aqueously dispersed phosphatidic acid Rattus norvegicus
3.1.3.4 Mn2+ activity with aqueously dispersed phosphatidic acid Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 cytosol
-
 Rattus norvegicus 5829
-
3.1.3.4 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 phosphatidic acid + H2O
-
 Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.4 6 6.5 and the major activity peak at pH 7.5-8.0, aqueously dispersed phosphatidic acid, cytosolic activity Rattus norvegicus
3.1.3.4 6.5
-
 and a minor peak of activity at pH 7.5-8, aqueously dispersed phosphatidic acid, microsomal enzyme Rattus norvegicus
3.1.3.4 6.5 7.5 membrane-bound phosphatidic acid, microsomal enzyme Rattus norvegicus
3.1.3.4 7.4 8 membrane-bound phosphatidic acid, cytosolic enzyme Rattus norvegicus
3.1.3.4 7.5 8 and a distinct optimum at pH 6.0-6.5, aqueously dispersed phosphatidic acid, cytosolic enzyme Rattus norvegicus