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Literature summary extracted from

  • Pallen, C.J.; Sharma, R.K.; Matsui, H.M.; Wang, J.H.
    Substrate specificity and metal activation of calcineurin (1985), Adv. Protein Phosphatases, 1, 147-162.
No PubMed abstract available

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.16 Ca2+ required by B subunit of calcineurin, four binding sites Mammalia
3.1.3.16 Fe2+ phosphatase 2B, i.e. calcineurin, metalloenzyme Mammalia
3.1.3.16 Zn2+ phosphatase 2B, i.e. calcineurin, metalloenzyme Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.16 phosphoprotein + H2O Mammalia role in cAMP catabolism protein + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Mammalia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 brain
-
 Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 phosphoprotein + H2O role in cAMP catabolism Mammalia protein + phosphate
-
 ?
3.1.3.16 phosphoproteins + H2O
-
 Mammalia proteins + phosphate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
3.1.3.16 Calmodulin requirement, phosphatase 2B, i.e. calcineurin Mammalia