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Literature summary extracted from

  • Ahmad, F.
    Free energy changes in ribonuclease A denaturation. Effect of urea, guanidine hydrochloride, and lithium salts (1983), J. Biol. Chem., 258, 11143-11146.
    View publication on PubMed

General Stability

EC Number General Stability Organism
4.6.1.18 guanidine hydrochloride causes denaturation Bos taurus
4.6.1.18 LiBr causes denaturation Bos taurus
4.6.1.18 LiCl, denaturation Bos taurus
4.6.1.18 LiClO4, denaturation Bos taurus
4.6.1.18 urea, denaturation, urea interferes with interhydrophobic interactions by affecting the water molecules Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.18 RNA + H2O Bos taurus endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
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 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.18 Bos taurus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.18 cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Bos taurus 3'-phosphomononucleotides
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 ir
4.6.1.18 RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Bos taurus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
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 ?
4.6.1.18 RNA + H2O first step of hydrolysis is reversible Bos taurus cyclic 2',3'-nucleoside monophosphate
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 r