EC Number | General Stability | Organism |
---|---|---|
4.6.1.18 | 2 M guanidine, activity remains | Bos taurus |
4.6.1.18 | 8 M urea, activity remains | Bos taurus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.18 | arsenite | - |
Bos taurus | |
4.6.1.18 | chloride | - |
Bos taurus | |
4.6.1.18 | Selenite | - |
Bos taurus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.18 | RNA + H2O | Mus musculus | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
4.6.1.18 | RNA + H2O | Homo sapiens | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
4.6.1.18 | RNA + H2O | Rattus norvegicus | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
4.6.1.18 | RNA + H2O | Sus scrofa | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
4.6.1.18 | RNA + H2O | Bos taurus | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.6.1.18 | Bos taurus | - |
- |
- |
4.6.1.18 | Homo sapiens | - |
- |
- |
4.6.1.18 | Mus musculus | - |
- |
- |
4.6.1.18 | Rattus norvegicus | - |
- |
- |
4.6.1.18 | Sus scrofa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.6.1.18 | - |
Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.6.1.18 | pancreas | - |
Mus musculus | - |
4.6.1.18 | pancreas | - |
Homo sapiens | - |
4.6.1.18 | pancreas | - |
Rattus norvegicus | - |
4.6.1.18 | pancreas | - |
Sus scrofa | - |
4.6.1.18 | pancreas | - |
Bos taurus | - |
4.6.1.18 | spleen | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.18 | cyclic 2',3'-nucleoside monophosphate + H2O | second step of hydrolysis is irreversible | Mus musculus | 3'-phosphomononucleotides | - |
ir | |
4.6.1.18 | cyclic 2',3'-nucleoside monophosphate + H2O | second step of hydrolysis is irreversible | Homo sapiens | 3'-phosphomononucleotides | - |
ir | |
4.6.1.18 | cyclic 2',3'-nucleoside monophosphate + H2O | second step of hydrolysis is irreversible | Rattus norvegicus | 3'-phosphomononucleotides | - |
ir | |
4.6.1.18 | cyclic 2',3'-nucleoside monophosphate + H2O | second step of hydrolysis is irreversible | Sus scrofa | 3'-phosphomononucleotides | - |
ir | |
4.6.1.18 | cyclic 2',3'-nucleoside monophosphate + H2O | second step of hydrolysis is irreversible | Bos taurus | 3'-phosphomononucleotides | - |
ir | |
4.6.1.18 | RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Mus musculus | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
4.6.1.18 | RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Homo sapiens | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
4.6.1.18 | RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Rattus norvegicus | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
4.6.1.18 | RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Sus scrofa | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
4.6.1.18 | RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Bos taurus | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
4.6.1.18 | RNA + H2O | first step of hydrolysis is reversible | Mus musculus | cyclic 2',3'-nucleoside monophosphate | - |
r | |
4.6.1.18 | RNA + H2O | first step of hydrolysis is reversible | Homo sapiens | cyclic 2',3'-nucleoside monophosphate | - |
r | |
4.6.1.18 | RNA + H2O | first step of hydrolysis is reversible | Rattus norvegicus | cyclic 2',3'-nucleoside monophosphate | - |
r | |
4.6.1.18 | RNA + H2O | first step of hydrolysis is reversible | Sus scrofa | cyclic 2',3'-nucleoside monophosphate | - |
r | |
4.6.1.18 | RNA + H2O | first step of hydrolysis is reversible | Bos taurus | cyclic 2',3'-nucleoside monophosphate | - |
r |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.6.1.18 | 6.5 | - |
- |
Rattus norvegicus |
4.6.1.18 | 7 | 7.5 | - |
Bos taurus |
4.6.1.18 | 7 | - |
- |
Mus musculus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
4.6.1.18 | 7 | 7.8 | - |
Homo sapiens |
4.6.1.18 | 7 | 7.8 | - |
Rattus norvegicus |
4.6.1.18 | 7 | 7.8 | - |
Bos taurus |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
4.6.1.18 | 2 | - |
activity remains below pH 2 | Bos taurus |