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Literature summary extracted from

  • Doersen, C.J.; Guerrier-Takada, C.; Altman, S.; Attardi, G.
    Characterization of an RNase P activity from HeLa cell mitochondria. Comparison with the cytosol RNase P activity (1985), J. Biol. Chem., 260, 5942-5949.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.26.5 ATP above 2 mM, progressively inhibitory Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.26.5 mitochondrion
-
 Homo sapiens 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.26.5 Cs+ less effective in activation than K+ Homo sapiens
3.1.26.5 K+
-
 Homo sapiens
3.1.26.5 Li+ less effective in activation than K+ Homo sapiens
3.1.26.5 Mg2+ required Homo sapiens
3.1.26.5 Na+ less effective in activation than K+ Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.26.5 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.26.5 ribonucleoprotein requires a RNA component Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.26.5 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.26.5 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.26.5 pre-tRNA precursor + H2O cleaves the precursor to E. coli suppressor tRNATyr at the same site as E. coli RNase P Homo sapiens tRNA + 5'-oligoribonucleotide
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.26.5 7.7 8.7
-
 Homo sapiens