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Literature summary extracted from
- Identification of deoxyribonuclease II as an endonuclease involved in apoptosis (1993), Arch. Biochem. Biophys., 300, 440-450.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.1.22.1 | resistant to heat and to incubation with proteinase K | Cricetulus griseus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.22.1 | Alkylating agents | - |
Cricetulus griseus | |
| 3.1.22.1 | aurintricarboxylic acid | - |
Cricetulus griseus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.22.1 | nucleus | - |
Cricetulus griseus | 5634 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.22.1 | 28000 | - |
gel filtration, SDS-PAGE | Cricetulus griseus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.22.1 | DNA + H2O | Cricetulus griseus | induces DNA digestion during apoptosis | oligonucleotides + ? | - |
? | |
| 3.1.22.1 | nuclei + H2O | Cricetulus griseus | convertes genomic DNA into fragments of less than 2 kbp | oligonucleotides + ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.22.1 | Cricetulus griseus | - |
chinese hamster | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.22.1 | partial | Cricetulus griseus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.22.1 | ovary | - |
Cricetulus griseus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.22.1 | DNA + H2O | induces DNA digestion during apoptosis | Cricetulus griseus | oligonucleotides + ? | - |
? | |
| 3.1.22.1 | linearized plasmid DNA + H2O | - |
Cricetulus griseus | oligonucleotides + ? | - |
? | |
| 3.1.22.1 | nuclei + H2O | convertes genomic DNA into fragments of less than 2 kbp | Cricetulus griseus | oligonucleotides + ? | - |
? | |
| 3.1.22.1 | supercoiled plasmid DNA + H2O | no sequence specificity | Cricetulus griseus | relaxed plasmid DNA + ? | primary reaction product, "nicking" mechanism | ? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.22.1 | 5 | - |
- |
Cricetulus griseus |
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Release 2023.1 (January 2023)
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