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Literature summary extracted from

  • Uotila, L.
    Glutathione thiol esterases (1989), Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York, 3, 767-804.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.6 glutathione
-
 Homo sapiens
3.1.2.6 glutathione
-
 Saccharomyces cerevisiae
3.1.2.6 methylglyoxal-glutathione hemimercaptal
-
 Bos taurus
3.1.2.6 methylglyoxal-glutathione hemimercaptal
-
 Homo sapiens
3.1.2.6 methylglyoxal-glutathione hemimercaptal
-
 Mus musculus
3.1.2.6 N,S-(dicarbobenzoxy)glutathione
-
 Rattus norvegicus
3.1.2.6 N-acetyl-S-(p-bromobenzyl)glutathione
-
 Bos taurus
3.1.2.6 N-acetyl-S-(p-bromobenzyl)glutathione
-
 Homo sapiens
3.1.2.6 N-acetyl-S-(p-bromobenzyl)glutathione
-
 Rattus norvegicus
3.1.2.6 N-benzoyl-S-(p-bromobenzyl)glutathione
-
 Rattus norvegicus
3.1.2.6 N-benzyloxycarbonyl-S-(p-bromobenzyl)glutathione
-
 Rattus norvegicus
3.1.2.6 S-(p-Azidophenacyl)-glutathione
-
 Bos taurus
3.1.2.6 S-(p-bromobenzyl)glutathione
-
 Bos taurus
3.1.2.6 S-(p-chlorophenacyl)glutathione
-
 Rattus norvegicus
3.1.2.6 S-benzyloxycarbonylglutathione
-
 Bos taurus
3.1.2.6 S-benzyloxycarbonylglutathione
-
 Rattus norvegicus
3.1.2.6 S-m-nitrobenzyloxycarbonylglutathione
-
 Bos taurus
3.1.2.6 S-m-nitrobenzyloxycarbonylglutathione
-
 Rattus norvegicus
3.1.2.6 S-o-nitrobenzyloxycarbonylglutathione
-
 Bos taurus
3.1.2.6 S-o-nitrobenzyloxycarbonylglutathione
-
 Rattus norvegicus
3.1.2.6 S-p-nitrobenzyloxycarbonylglutathione
-
 Bos taurus
3.1.2.6 S-p-nitrobenzyloxycarbonylglutathione
-
 Homo sapiens
3.1.2.6 S-p-nitrobenzyloxycarbonylglutathione
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.2.6 additional information
-
 additional information
-
 Homo sapiens
3.1.2.6 additional information
-
 additional information
-
 Saccharomyces cerevisiae
3.1.2.6 0.014
-
 S-mandeloylglutathione enzyme from erythrocytes Rattus norvegicus
3.1.2.6 0.015
-
 S-mandeloylglutathione enzyme from brain Homo sapiens
3.1.2.6 0.016
-
 S-mandeloylglutathione enzyme from liver Homo sapiens
3.1.2.6 0.07
-
 S-glycolylglutathione enzyme from liver Homo sapiens
3.1.2.6 0.109
-
 S-glyceroylglutathione enzyme from liver Homo sapiens
3.1.2.6 0.153
-
 S-formylglutathione enzyme from liver Homo sapiens
3.1.2.6 0.18
-
 S-Lactoylglutathione enzyme from erythrocytes Rattus norvegicus
3.1.2.6 0.19
-
 S-Lactoylglutathione enzyme from liver Homo sapiens
3.1.2.6 0.2
-
 S-succinylglutathione enzyme from liver Homo sapiens
3.1.2.6 0.21
-
 S-Lactoylglutathione enzyme from liver Rattus norvegicus
3.1.2.6 0.213
-
 S-propionylglutathione enzyme from liver Homo sapiens
3.1.2.6 0.266
-
 S-acetylglutathione enzyme from liver Homo sapiens
3.1.2.6 0.27
-
 S-D-lactoylglutathione enzyme from liver Mus musculus
3.1.2.6 0.295
-
 S-Acetoacetylglutathione enzyme from liver Homo sapiens
3.1.2.6 0.304
-
 S-Lactoylglutathione enzyme from brain Homo sapiens
3.1.2.6 0.325
-
 S-Lactoylglutathione enzyme from calf brain Bos taurus
3.1.2.6 1.16
-
 S-glycolylglutathione brain Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.6 21000
-
 gel filtration Homo sapiens
3.1.2.6 21000
-
 gel filtration Rattus norvegicus
3.1.2.6 21900
-
 erythrocytes, gel filtration Rattus norvegicus
3.1.2.6 22500
-
 x * 22500, bovine liver, SDS-PAGE Bos taurus
3.1.2.6 22900
-
 gel filtration Homo sapiens
3.1.2.6 23000
-
 calf brain, gel filtration Bos taurus
3.1.2.6 24000
-
-
 Homo sapiens
3.1.2.6 24000
-
 gel filtration Rattus norvegicus
3.1.2.6 29500
-
 1 * 29500, SDS-PAGE Mus musculus
3.1.2.6 30000
-
 x * 30000, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.6 Bos taurus
-
-
-
3.1.2.6 Escherichia coli
-
-
-
3.1.2.6 Homo sapiens
-
-
-
3.1.2.6 Mus musculus
-
-
-
3.1.2.6 Rattus norvegicus
-
-
-
3.1.2.6 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.2.6
-
 Homo sapiens
3.1.2.6
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.6 brain
-
 Homo sapiens
-
3.1.2.6 brain
-
 Rattus norvegicus
-
3.1.2.6 brain
-
 Bos taurus
-
3.1.2.6 erythrocyte
-
 Homo sapiens
-
3.1.2.6 erythrocyte
-
 Rattus norvegicus
-
3.1.2.6 liver
-
 Mus musculus
-
3.1.2.6 liver
-
 Homo sapiens
-
3.1.2.6 liver
-
 Rattus norvegicus
-
3.1.2.6 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.6 lactoylglutathione + H2O
-
 Mus musculus D-lactate + glutathione
-
 ?
3.1.2.6 lactoylglutathione + H2O
-
 Homo sapiens D-lactate + glutathione
-
 ?
3.1.2.6 lactoylglutathione + H2O
-
 Rattus norvegicus D-lactate + glutathione
-
 ?
3.1.2.6 lactoylglutathione + H2O
-
 Saccharomyces cerevisiae D-lactate + glutathione
-
 ?
3.1.2.6 lactoylglutathione + H2O
-
 Bos taurus D-lactate + glutathione
-
 ?
3.1.2.6 S-acetoacetylglutathione + H2O
-
 Homo sapiens acetoacetate + glutathione
-
 ?
3.1.2.6 S-acetoacetylglutathione + H2O
-
 Rattus norvegicus acetoacetate + glutathione
-
 ?
3.1.2.6 S-acetoacetylglutathione + H2O
-
 Bos taurus acetoacetate + glutathione
-
 ?
3.1.2.6 S-acetylglutathione + H2O
-
 Homo sapiens acetate + glutathione
-
 ?
3.1.2.6 S-acetylglutathione + H2O
-
 Rattus norvegicus acetate + glutathione
-
 ?
3.1.2.6 S-acetylglutathione + H2O
-
 Bos taurus acetate + glutathione
-
 ?
3.1.2.6 S-D-lactoylglutathione + H2O
-
 Mus musculus D-lactate + glutathione
-
 ?
3.1.2.6 S-formylglutathione + H2O
-
 Homo sapiens formate + glutathione
-
 ?
3.1.2.6 S-formylglutathione + H2O
-
 Rattus norvegicus formate + glutathione
-
 ?
3.1.2.6 S-glyceroylglutathione + H2O
-
 Homo sapiens glycerate + glutathione
-
 ?
3.1.2.6 S-glycerylglutathione + H2O
-
 Homo sapiens glycerate + glutathione
-
 ?
3.1.2.6 S-glycoloylglutathione + H2O
-
 Homo sapiens glycolate + glutathione
-
 ?
3.1.2.6 S-lactoylglutathione + H2O
-
 Homo sapiens D-lactate + glutathione
-
 ?
3.1.2.6 S-mandeloylglutathione + H2O
-
 Homo sapiens mandelate + glutathione
-
 ?
3.1.2.6 S-mandeloylglutathione + H2O
-
 Rattus norvegicus mandelate + glutathione
-
 ?
3.1.2.6 S-mandeloylglutathione + H2O
-
 Saccharomyces cerevisiae mandelate + glutathione
-
 ?
3.1.2.6 S-propionylglutathione + H2O
-
 Homo sapiens propionate + glutathione
-
 ?
3.1.2.6 S-propionylglutathione + H2O
-
 Rattus norvegicus propionate + glutathione
-
 ?
3.1.2.6 S-succinylglutathione + H2O
-
 Homo sapiens succinate + glutathione
-
 ?
3.1.2.6 S-succinylglutathione + H2O
-
 Rattus norvegicus succinate + glutathione
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.2.6 ?
-
 Homo sapiens
3.1.2.6 ?
-
 Saccharomyces cerevisiae
3.1.2.6 ? x * 30000, SDS-PAGE Rattus norvegicus
3.1.2.6 ? x * 22500, bovine liver, SDS-PAGE Bos taurus
3.1.2.6 monomer
-
 Homo sapiens
3.1.2.6 monomer
-
 Saccharomyces cerevisiae
3.1.2.6 monomer 1 * 29500, SDS-PAGE Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.6 6.8 7.5
-
 Homo sapiens