BRENDA - Enzyme Database

Glutathione thiol esterases

Uotila, L.; Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York 3, 767-804 (1989)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.2.6
glutathione
-
Homo sapiens
3.1.2.6
glutathione
-
Saccharomyces cerevisiae
3.1.2.6
methylglyoxal-glutathione hemimercaptal
-
Bos taurus
3.1.2.6
methylglyoxal-glutathione hemimercaptal
-
Homo sapiens
3.1.2.6
methylglyoxal-glutathione hemimercaptal
-
Mus musculus
3.1.2.6
N,S-(dicarbobenzoxy)glutathione
-
Rattus norvegicus
3.1.2.6
N-acetyl-S-(p-bromobenzyl)glutathione
-
Bos taurus
3.1.2.6
N-acetyl-S-(p-bromobenzyl)glutathione
-
Homo sapiens
3.1.2.6
N-acetyl-S-(p-bromobenzyl)glutathione
-
Rattus norvegicus
3.1.2.6
N-benzoyl-S-(p-bromobenzyl)glutathione
-
Rattus norvegicus
3.1.2.6
N-benzyloxycarbonyl-S-(p-bromobenzyl)glutathione
-
Rattus norvegicus
3.1.2.6
S-(p-Azidophenacyl)-glutathione
-
Bos taurus
3.1.2.6
S-(p-bromobenzyl)glutathione
-
Bos taurus
3.1.2.6
S-(p-chlorophenacyl)glutathione
-
Rattus norvegicus
3.1.2.6
S-benzyloxycarbonylglutathione
-
Rattus norvegicus
3.1.2.6
S-benzyloxycarbonylglutathione
-
Bos taurus
3.1.2.6
S-m-nitrobenzyloxycarbonylglutathione
-
Rattus norvegicus
3.1.2.6
S-m-nitrobenzyloxycarbonylglutathione
-
Bos taurus
3.1.2.6
S-o-nitrobenzyloxycarbonylglutathione
-
Rattus norvegicus
3.1.2.6
S-o-nitrobenzyloxycarbonylglutathione
-
Bos taurus
3.1.2.6
S-p-nitrobenzyloxycarbonylglutathione
-
Homo sapiens
3.1.2.6
S-p-nitrobenzyloxycarbonylglutathione
-
Rattus norvegicus
3.1.2.6
S-p-nitrobenzyloxycarbonylglutathione
-
Bos taurus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.1.2.6
additional information
-
additional information
-
Homo sapiens
3.1.2.6
additional information
-
additional information
-
Saccharomyces cerevisiae
3.1.2.6
0.014
-
S-mandeloylglutathione
enzyme from erythrocytes
Rattus norvegicus
3.1.2.6
0.015
-
S-mandeloylglutathione
enzyme from brain
Homo sapiens
3.1.2.6
0.016
-
S-mandeloylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.07
-
S-glycolylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.109
-
S-glyceroylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.153
-
S-formylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.18
-
S-Lactoylglutathione
enzyme from erythrocytes
Rattus norvegicus
3.1.2.6
0.19
-
S-lactylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.2
-
S-succinylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.21
-
S-Lactoylglutathione
enzyme from liver
Rattus norvegicus
3.1.2.6
0.213
-
S-propionylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.266
-
S-acetylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.27
-
S-D-lactoylglutathione
enzyme from liver
Mus musculus
3.1.2.6
0.295
-
S-Acetoacetylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.304
-
S-Lactoylglutathione
enzyme from brain
Homo sapiens
3.1.2.6
0.325
-
S-Lactoylglutathione
enzyme from calf brain
Bos taurus
3.1.2.6
1.16
-
S-glycolylglutathione
brain
Homo sapiens
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.1.2.6
21000
-
gel filtration
Homo sapiens
3.1.2.6
21000
-
gel filtration
Rattus norvegicus
3.1.2.6
21900
-
erythrocytes, gel filtration
Rattus norvegicus
3.1.2.6
22500
-
x * 22500, bovine liver, SDS-PAGE
Bos taurus
3.1.2.6
22900
-
gel filtration
Homo sapiens
3.1.2.6
23000
-
calf brain, gel filtration
Bos taurus
3.1.2.6
24000
-
-
Homo sapiens
3.1.2.6
24000
-
gel filtration
Rattus norvegicus
3.1.2.6
29500
-
1 * 29500, SDS-PAGE
Mus musculus
3.1.2.6
30000
-
x * 30000, SDS-PAGE
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.2.6
Bos taurus
-
-
-
3.1.2.6
Escherichia coli
-
-
-
3.1.2.6
Homo sapiens
-
-
-
3.1.2.6
Mus musculus
-
-
-
3.1.2.6
Rattus norvegicus
-
-
-
3.1.2.6
Saccharomyces cerevisiae
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.1.2.6
-
Rattus norvegicus
3.1.2.6
-
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.2.6
brain
-
Bos taurus
-
3.1.2.6
brain
-
Homo sapiens
-
3.1.2.6
brain
-
Rattus norvegicus
-
3.1.2.6
erythrocyte
-
Rattus norvegicus
-
3.1.2.6
erythrocyte
-
Homo sapiens
-
3.1.2.6
liver
-
Bos taurus
-
3.1.2.6
liver
-
Rattus norvegicus
-
3.1.2.6
liver
-
Mus musculus
-
3.1.2.6
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.2.6
lactoylglutathione + H2O
-
134180
Mus musculus
D-lactate + glutathione
-
-
-
?
3.1.2.6
lactoylglutathione + H2O
-
134180
Homo sapiens
D-lactate + glutathione
-
-
-
?
3.1.2.6
lactoylglutathione + H2O
-
134180
Rattus norvegicus
D-lactate + glutathione
-
-
-
?
3.1.2.6
lactoylglutathione + H2O
-
134180
Saccharomyces cerevisiae
D-lactate + glutathione
-
-
-
?
3.1.2.6
lactoylglutathione + H2O
-
134180
Bos taurus
D-lactate + glutathione
-
-
-
?
3.1.2.6
S-acetoacetylglutathione + H2O
-
134180
Homo sapiens
acetoacetate + glutathione
-
-
-
?
3.1.2.6
S-acetoacetylglutathione + H2O
-
134180
Rattus norvegicus
acetoacetate + glutathione
-
-
-
?
3.1.2.6
S-acetoacetylglutathione + H2O
-
134180
Bos taurus
acetoacetate + glutathione
-
-
-
?
3.1.2.6
S-acetylglutathione + H2O
-
134180
Homo sapiens
acetate + glutathione
-
-
-
?
3.1.2.6
S-acetylglutathione + H2O
-
134180
Rattus norvegicus
acetate + glutathione
-
-
-
?
3.1.2.6
S-acetylglutathione + H2O
-
134180
Bos taurus
acetate + glutathione
-
-
-
?
3.1.2.6
S-D-lactoylglutathione + H2O
-
134180
Mus musculus
D-lactate + glutathione
-
-
-
-
3.1.2.6
S-formylglutathione + H2O
-
134180
Homo sapiens
formate + glutathione
-
-
-
?
3.1.2.6
S-formylglutathione + H2O
-
134180
Rattus norvegicus
formate + glutathione
-
-
-
?
3.1.2.6
S-glycerylglutathione + H2O
-
134180
Homo sapiens
glycerate + glutathione
-
-
-
?
3.1.2.6
S-glycoloylglutathione + H2O
-
134180
Homo sapiens
glycolate + glutathione
-
-
-
?
3.1.2.6
S-mandeloylglutathione + H2O
-
134180
Homo sapiens
mandelate + glutathione
-
-
-
?
3.1.2.6
S-mandeloylglutathione + H2O
-
134180
Saccharomyces cerevisiae
mandelate + glutathione
-
-
-
?
3.1.2.6
S-propionylglutathione + H2O
-
134180
Homo sapiens
propionate + glutathione
-
-
-
?
3.1.2.6
S-propionylglutathione + H2O
-
134180
Rattus norvegicus
propionate + glutathione
-
-
-
?
3.1.2.6
S-succinylglutathione + H2O
-
134180
Homo sapiens
succinate + glutathione
-
-
-
?
3.1.2.6
S-succinylglutathione + H2O
-
134180
Rattus norvegicus
succinate + glutathione
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
3.1.2.6
?
x * 22500, bovine liver, SDS-PAGE
Bos taurus
3.1.2.6
?
-
Homo sapiens
3.1.2.6
?
x * 30000, SDS-PAGE
Rattus norvegicus
3.1.2.6
?
-
Saccharomyces cerevisiae
3.1.2.6
monomer
-
Homo sapiens
3.1.2.6
monomer
1 * 29500, SDS-PAGE
Mus musculus
3.1.2.6
monomer
-
Saccharomyces cerevisiae
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.1.2.6
6.8
7.5
-
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.2.6
glutathione
-
Homo sapiens
3.1.2.6
glutathione
-
Saccharomyces cerevisiae
3.1.2.6
methylglyoxal-glutathione hemimercaptal
-
Bos taurus
3.1.2.6
methylglyoxal-glutathione hemimercaptal
-
Homo sapiens
3.1.2.6
methylglyoxal-glutathione hemimercaptal
-
Mus musculus
3.1.2.6
N,S-(dicarbobenzoxy)glutathione
-
Rattus norvegicus
3.1.2.6
N-acetyl-S-(p-bromobenzyl)glutathione
-
Bos taurus
3.1.2.6
N-acetyl-S-(p-bromobenzyl)glutathione
-
Homo sapiens
3.1.2.6
N-acetyl-S-(p-bromobenzyl)glutathione
-
Rattus norvegicus
3.1.2.6
N-benzoyl-S-(p-bromobenzyl)glutathione
-
Rattus norvegicus
3.1.2.6
N-benzyloxycarbonyl-S-(p-bromobenzyl)glutathione
-
Rattus norvegicus
3.1.2.6
S-(p-Azidophenacyl)-glutathione
-
Bos taurus
3.1.2.6
S-(p-bromobenzyl)glutathione
-
Bos taurus
3.1.2.6
S-(p-chlorophenacyl)glutathione
-
Rattus norvegicus
3.1.2.6
S-benzyloxycarbonylglutathione
-
Rattus norvegicus
3.1.2.6
S-benzyloxycarbonylglutathione
-
Bos taurus
3.1.2.6
S-m-nitrobenzyloxycarbonylglutathione
-
Rattus norvegicus
3.1.2.6
S-m-nitrobenzyloxycarbonylglutathione
-
Bos taurus
3.1.2.6
S-o-nitrobenzyloxycarbonylglutathione
-
Rattus norvegicus
3.1.2.6
S-o-nitrobenzyloxycarbonylglutathione
-
Bos taurus
3.1.2.6
S-p-nitrobenzyloxycarbonylglutathione
-
Homo sapiens
3.1.2.6
S-p-nitrobenzyloxycarbonylglutathione
-
Rattus norvegicus
3.1.2.6
S-p-nitrobenzyloxycarbonylglutathione
-
Bos taurus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.1.2.6
additional information
-
additional information
-
Homo sapiens
3.1.2.6
additional information
-
additional information
-
Saccharomyces cerevisiae
3.1.2.6
0.014
-
S-mandeloylglutathione
enzyme from erythrocytes
Rattus norvegicus
3.1.2.6
0.015
-
S-mandeloylglutathione
enzyme from brain
Homo sapiens
3.1.2.6
0.016
-
S-mandeloylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.07
-
S-glycolylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.109
-
S-glyceroylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.153
-
S-formylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.18
-
S-Lactoylglutathione
enzyme from erythrocytes
Rattus norvegicus
3.1.2.6
0.19
-
S-lactylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.2
-
S-succinylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.21
-
S-Lactoylglutathione
enzyme from liver
Rattus norvegicus
3.1.2.6
0.213
-
S-propionylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.266
-
S-acetylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.27
-
S-D-lactoylglutathione
enzyme from liver
Mus musculus
3.1.2.6
0.295
-
S-Acetoacetylglutathione
enzyme from liver
Homo sapiens
3.1.2.6
0.304
-
S-Lactoylglutathione
enzyme from brain
Homo sapiens
3.1.2.6
0.325
-
S-Lactoylglutathione
enzyme from calf brain
Bos taurus
3.1.2.6
1.16
-
S-glycolylglutathione
brain
Homo sapiens
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.1.2.6
21000
-
gel filtration
Homo sapiens
3.1.2.6
21000
-
gel filtration
Rattus norvegicus
3.1.2.6
21900
-
erythrocytes, gel filtration
Rattus norvegicus
3.1.2.6
22500
-
x * 22500, bovine liver, SDS-PAGE
Bos taurus
3.1.2.6
22900
-
gel filtration
Homo sapiens
3.1.2.6
23000
-
calf brain, gel filtration
Bos taurus
3.1.2.6
24000
-
-
Homo sapiens
3.1.2.6
24000
-
gel filtration
Rattus norvegicus
3.1.2.6
29500
-
1 * 29500, SDS-PAGE
Mus musculus
3.1.2.6
30000
-
x * 30000, SDS-PAGE
Rattus norvegicus
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.2.6
-
Rattus norvegicus
3.1.2.6
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.2.6
brain
-
Bos taurus
-
3.1.2.6
brain
-
Homo sapiens
-
3.1.2.6
brain
-
Rattus norvegicus
-
3.1.2.6
erythrocyte
-
Rattus norvegicus
-
3.1.2.6
erythrocyte
-
Homo sapiens
-
3.1.2.6
liver
-
Bos taurus
-
3.1.2.6
liver
-
Rattus norvegicus
-
3.1.2.6
liver
-
Mus musculus
-
3.1.2.6
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.2.6
lactoylglutathione + H2O
-
134180
Mus musculus
D-lactate + glutathione
-
-
-
?
3.1.2.6
lactoylglutathione + H2O
-
134180
Homo sapiens
D-lactate + glutathione
-
-
-
?
3.1.2.6
lactoylglutathione + H2O
-
134180
Rattus norvegicus
D-lactate + glutathione
-
-
-
?
3.1.2.6
lactoylglutathione + H2O
-
134180
Saccharomyces cerevisiae
D-lactate + glutathione
-
-
-
?
3.1.2.6
lactoylglutathione + H2O
-
134180
Bos taurus
D-lactate + glutathione
-
-
-
?
3.1.2.6
S-acetoacetylglutathione + H2O
-
134180
Homo sapiens
acetoacetate + glutathione
-
-
-
?
3.1.2.6
S-acetoacetylglutathione + H2O
-
134180
Rattus norvegicus
acetoacetate + glutathione
-
-
-
?
3.1.2.6
S-acetoacetylglutathione + H2O
-
134180
Bos taurus
acetoacetate + glutathione
-
-
-
?
3.1.2.6
S-acetylglutathione + H2O
-
134180
Homo sapiens
acetate + glutathione
-
-
-
?
3.1.2.6
S-acetylglutathione + H2O
-
134180
Rattus norvegicus
acetate + glutathione
-
-
-
?
3.1.2.6
S-acetylglutathione + H2O
-
134180
Bos taurus
acetate + glutathione
-
-
-
?
3.1.2.6
S-D-lactoylglutathione + H2O
-
134180
Mus musculus
D-lactate + glutathione
-
-
-
-
3.1.2.6
S-formylglutathione + H2O
-
134180
Homo sapiens
formate + glutathione
-
-
-
?
3.1.2.6
S-formylglutathione + H2O
-
134180
Rattus norvegicus
formate + glutathione
-
-
-
?
3.1.2.6
S-glycerylglutathione + H2O
-
134180
Homo sapiens
glycerate + glutathione
-
-
-
?
3.1.2.6
S-glycoloylglutathione + H2O
-
134180
Homo sapiens
glycolate + glutathione
-
-
-
?
3.1.2.6
S-mandeloylglutathione + H2O
-
134180
Homo sapiens
mandelate + glutathione
-
-
-
?
3.1.2.6
S-mandeloylglutathione + H2O
-
134180
Saccharomyces cerevisiae
mandelate + glutathione
-
-
-
?
3.1.2.6
S-propionylglutathione + H2O
-
134180
Homo sapiens
propionate + glutathione
-
-
-
?
3.1.2.6
S-propionylglutathione + H2O
-
134180
Rattus norvegicus
propionate + glutathione
-
-
-
?
3.1.2.6
S-succinylglutathione + H2O
-
134180
Homo sapiens
succinate + glutathione
-
-
-
?
3.1.2.6
S-succinylglutathione + H2O
-
134180
Rattus norvegicus
succinate + glutathione
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
3.1.2.6
?
x * 22500, bovine liver, SDS-PAGE
Bos taurus
3.1.2.6
?
-
Homo sapiens
3.1.2.6
?
x * 30000, SDS-PAGE
Rattus norvegicus
3.1.2.6
?
-
Saccharomyces cerevisiae
3.1.2.6
monomer
-
Homo sapiens
3.1.2.6
monomer
1 * 29500, SDS-PAGE
Mus musculus
3.1.2.6
monomer
-
Saccharomyces cerevisiae
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.1.2.6
6.8
7.5
-
Homo sapiens