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Literature summary extracted from
- Characterization of fetal serum 5'-nucleotide phosphodiesterase: A novel function as a platelet aggregation inhibitor in fetal circulation (1998), Thromb. Res., 91, 83-89.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.1 | 5'-nucleotides | end-product inhibition | Homo sapiens |  |
| 3.1.4.1 | ADP | competitive | Homo sapiens | |
| 3.1.4.1 | AMP | 5'-AMP, but 2'-AMP, 3'-AMP, 3': 5'cAMP and 2': 3'cAMP has no inhibiting effects; competitive; product inhibition | Homo sapiens | |
| 3.1.4.1 | ATP | - |
Homo sapiens | |
| 3.1.4.1 | Citric acid | slight inhibition | Homo sapiens | |
| 3.1.4.1 | cystine | slight inhibition | Homo sapiens | |
| 3.1.4.1 | diphosphate | slight inhibition | Homo sapiens | |
| 3.1.4.1 | EDTA | - |
Homo sapiens | |
| 3.1.4.1 | EGTA | - |
Homo sapiens | |
| 3.1.4.1 | additional information | no inhibition by adenosine, inosine, phenylalanine and caffeine | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.4.1 | microsome | - |
Homo sapiens | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.1 | 128000 | - |
fetal, gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.1 | additional information | Homo sapiens | enzyme may be involved in nucleotides metabolism in human plasma | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.1 | Homo sapiens | - |
fetal, origin of the fetal serum PDEase might be a soluble form of human PC-1, a plasma cell membrane glycoprotein, with a molecular weight of 130000 Da, which possesses alkaline phosphodiesterase I and nucleotide pyrophosphatase activity | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.4.1 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.1 | serum | umbilical cord blood serum | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.1 | 0.103 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.1 | ADP + H2O | ADPase activity, hydrolysis of ADP by human plasma PDEase acts as an inhibitor of platelet aggregation | Homo sapiens | AMP + phosphate | - |
? | |
| 3.1.4.1 | additional information | enzyme may be involved in nucleotides metabolism in human plasma | Homo sapiens | ? | - |
? | |
| 3.1.4.1 | oligonucleotides + H2O | specific for 3'-5'-direction from the 3'-hydroxyl terminal in a stepwise manner | Homo sapiens | oligonucleotides(n-1) + 5'-mononucleotides | - |
? | |
| 3.1.4.1 | p-nitrophenylthymidine 5'-phosphate + H2O | - |
Homo sapiens | 5'-TMP + p-nitrophenol | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.1 | PDEase | - |
Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.1 | 8.9 | - |
- |
Homo sapiens |
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