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Literature summary extracted from

  • Dessen, A.; Tang, J.; Schmidt, H.; Stahl, M.; Clark, J.D.; Seehra, J.; Somers, W.S.
    Crystal structure of human cytosolic Phospholipase A2 reveals a novel topology and catalytic mechanism (1999), Cell, 97, 349-360.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.4 full length human cPLA2, residues 1-749, expressed in E5-CHO-cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.4 cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.4 Ca2+ structure of Ca2+-binding site Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.4 phospholipids + H2O Homo sapiens influence on platelet aggregation ?
-
 ?
3.1.1.4 phospholipids + H2O Homo sapiens inflammatory diseases ?
-
 ?
3.1.1.4 phospholipids + H2O Homo sapiens release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.4 gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O cPLA2 cleaves selectively arachidonoyl phospholipids Homo sapiens 1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
 ?
3.1.1.4 1-stearoyl-2-arachidonoylphosphatidylcholine + H2O cPLA2 cleaves selectively arachidonoyl containing phospholipids Homo sapiens 1-stearoyl-glycerophosphorylcholine + arachidonic acid
-
 ?
3.1.1.4 phospholipids + H2O influence on platelet aggregation Homo sapiens ?
-
 ?
3.1.1.4 phospholipids + H2O inflammatory diseases Homo sapiens ?
-
 ?
3.1.1.4 phospholipids + H2O release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.4 monomer cPLA2, no data concerning MW Homo sapiens