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Literature summary extracted from

  • Yang, H-C.; Mosior, M.; Ni, B.; Dennis, E.A.
    Regional distribution, ontogeny, purification, and characterization of the Ca2+-independent phospholipase A2 from rat brain (1999), J. Neurochem., 73, 1278-1287.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 pure phospholipid vesicles exception: vesicles composed of phosphatidylcholine or phosphatidylinositol 4,5-bisphosphate Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.4 cytoplasm
-
 Rattus norvegicus 5737
-
3.1.1.4 secretory granule
-
 Rattus norvegicus 30141
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.4 Ca2+
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.4 80000
-
 SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.4 phospholipids + H2O Rattus norvegicus influence on platelet aggregation ?
-
 ?
3.1.1.4 phospholipids + H2O Rattus norvegicus release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.4 30000fold from rat brain, 90% pure protein Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 brain iPLA2 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.4 0.6
-
 iPLA2 in a 30000fold purification, substrate: 1-stearoyl-2-arachidonoylphosphatidylcholine Rattus norvegicus
3.1.1.4 2
-
 iPLA2 in a 30000fold purification, substrate: 1-palmitoyl-2-arachidonoylphosphatidylcholine Rattus norvegicus
3.1.1.4 3
-
 iPLA2 in a 30000fold purification, substrate: 1-palmitoyl-2-oleolylphosphatidylcholine Rattus norvegicus
3.1.1.4 4.3
-
 iPLA2 in a 30000fold purification, substrate: 1,2-dipalmitoyl-phosphatidylcholine Rattus norvegicus
3.1.1.4 5.9
-
 iPLA2 in a 30000fold purification, substrate: 1-palmitoyl-2-linoleoylphosphatidylethanolamine Rattus norvegicus
3.1.1.4 10
-
 iPLA2 in a 30000fold purification, substrate: 1-palmitoyl-2-linoleoylphosphatidylcholine Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1,2-dipalmitoyl-phosphatidylcholine + H2O data for iPLA2 Rattus norvegicus 1-palmitoyl-glycerophosphorylcholine + palmitic acid
-
 ?
3.1.1.4 1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O ,data for iPLA2 Rattus norvegicus 1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
 ?
3.1.1.4 1-palmitoyl-2-linoleoylphosphatidylcholine + H2O iPLA2 Rattus norvegicus 1-palmitoyl-glycerophosphorylcholine + linolic acid
-
 ?
3.1.1.4 1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O data for iPLA2 Rattus norvegicus 1-palmitoyl-glycerophosphorylethanolamine + linolic acid
-
 ?
3.1.1.4 1-palmitoyl-2-oleoylphosphatidylcholine + H2O data for iPLA2 Rattus norvegicus 1-palmitoyl-glycerophosphocholine + oleic acid
-
 ?
3.1.1.4 1-stearoyl-2-arachidonoylphosphatidylcholine + H2O data for iPLA2 Rattus norvegicus 1-stearoyl-glycerophosphorylcholine + arachidonic acid
-
 ?
3.1.1.4 phospholipids + H2O influence on platelet aggregation Rattus norvegicus ?
-
 ?
3.1.1.4 phospholipids + H2O release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins Rattus norvegicus ?
-
 ?