BRENDA - Enzyme Database

Cytoplasmic steps of peptidoglycan synthesis in Escherichia coli

Mengin-Lecreulx, D.; Flouret, B.; Van Heijenoort, J.; J. Bacteriol. 151, 1109-1117 (1982)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
6.3.2.9
UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
Escherichia coli
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
6.3.2.8
0.2
-
L-Ala
-
Escherichia coli
6.3.2.8
0.3
-
UDP-N-acetylmuramate
-
Escherichia coli
6.3.2.9
0.03
-
UDP-N-acetylmuramoyl-L-Ala
-
Escherichia coli
6.3.2.9
0.13
-
D-Glu
-
Escherichia coli
6.3.2.13
0.035
-
UDP-N-MurNAc-L-Ala-D-Glu
-
Escherichia coli
6.3.2.13
0.036
-
meso-2,6-diaminoheptanedioate
-
Escherichia coli
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
6.3.2.8
ATP + UDP-N-acetylmuramate + L-Ala
Escherichia coli
enzyme activity is not in excess in the cell under normal growth conditions, but the amount is adjusted to the requirements of peptidoglycan synthesis
?
-
-
?
6.3.2.9
ATP + UDP-N-acetylmuramoyl-L-Ala + Glu
Escherichia coli
activity is not in excess in the cell under normal growth conditions, but its amount is adjusted to the requirements of peptidoglycan synthesis
?
-
-
?
6.3.2.13
ATP + UDP-N-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate
Escherichia coli
the adding activity is not in excess in the cell under normal growth conditions, but their amounts appear adjusted to the requirements of peptidoglycan synthesis
?
-
-
?
Organism
EC Number
Organism
UniProt
Commentary
Textmining
6.3.2.8
Escherichia coli
-
K12
-
6.3.2.9
Escherichia coli
-
K12
-
6.3.2.13
Escherichia coli
-
K12
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
6.3.2.8
ATP + UDP-N-acetylmuramate + L-Ala
-
1276
Escherichia coli
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
-
-
?
6.3.2.8
ATP + UDP-N-acetylmuramate + L-Ala
enzyme activity is not in excess in the cell under normal growth conditions, but the amount is adjusted to the requirements of peptidoglycan synthesis
1276
Escherichia coli
?
-
-
-
?
6.3.2.9
ATP + UDP-N-acetylmuramoyl-L-Ala + Glu
-
1276
Escherichia coli
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
-
-
?
6.3.2.9
ATP + UDP-N-acetylmuramoyl-L-Ala + Glu
activity is not in excess in the cell under normal growth conditions, but its amount is adjusted to the requirements of peptidoglycan synthesis
1276
Escherichia coli
?
-
-
-
?
6.3.2.13
ATP + UDP-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate
-
1276
Escherichia coli
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate
-
-
-
?
6.3.2.13
ATP + UDP-N-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate
the adding activity is not in excess in the cell under normal growth conditions, but their amounts appear adjusted to the requirements of peptidoglycan synthesis
1276
Escherichia coli
?
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
6.3.2.9
UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
Escherichia coli
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
6.3.2.8
0.2
-
L-Ala
-
Escherichia coli
6.3.2.8
0.3
-
UDP-N-acetylmuramate
-
Escherichia coli
6.3.2.9
0.03
-
UDP-N-acetylmuramoyl-L-Ala
-
Escherichia coli
6.3.2.9
0.13
-
D-Glu
-
Escherichia coli
6.3.2.13
0.035
-
UDP-N-MurNAc-L-Ala-D-Glu
-
Escherichia coli
6.3.2.13
0.036
-
meso-2,6-diaminoheptanedioate
-
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
6.3.2.8
ATP + UDP-N-acetylmuramate + L-Ala
Escherichia coli
enzyme activity is not in excess in the cell under normal growth conditions, but the amount is adjusted to the requirements of peptidoglycan synthesis
?
-
-
?
6.3.2.9
ATP + UDP-N-acetylmuramoyl-L-Ala + Glu
Escherichia coli
activity is not in excess in the cell under normal growth conditions, but its amount is adjusted to the requirements of peptidoglycan synthesis
?
-
-
?
6.3.2.13
ATP + UDP-N-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate
Escherichia coli
the adding activity is not in excess in the cell under normal growth conditions, but their amounts appear adjusted to the requirements of peptidoglycan synthesis
?
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
6.3.2.8
ATP + UDP-N-acetylmuramate + L-Ala
-
1276
Escherichia coli
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
-
-
?
6.3.2.8
ATP + UDP-N-acetylmuramate + L-Ala
enzyme activity is not in excess in the cell under normal growth conditions, but the amount is adjusted to the requirements of peptidoglycan synthesis
1276
Escherichia coli
?
-
-
-
?
6.3.2.9
ATP + UDP-N-acetylmuramoyl-L-Ala + Glu
-
1276
Escherichia coli
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
-
-
?
6.3.2.9
ATP + UDP-N-acetylmuramoyl-L-Ala + Glu
activity is not in excess in the cell under normal growth conditions, but its amount is adjusted to the requirements of peptidoglycan synthesis
1276
Escherichia coli
?
-
-
-
?
6.3.2.13
ATP + UDP-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate
-
1276
Escherichia coli
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate
-
-
-
?
6.3.2.13
ATP + UDP-N-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate
the adding activity is not in excess in the cell under normal growth conditions, but their amounts appear adjusted to the requirements of peptidoglycan synthesis
1276
Escherichia coli
?
-
-
-
?