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Literature summary for 7.6.2.8 extracted from

  • Sonne, J.; Kandt, C.; Peters, G.H.; Hansen, F.Y.; Jensen, M.?.; Tieleman, D.P.
    Simulation of the coupling between nucleotide binding and transmembrane domains in the ATP binding cassette transporter BtuCD (2007), Biophys. J., 92, 2727-2734.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + vitamin B12/out Escherichia coli
-
 ADP + phosphate + vitamin B12/in
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P37028
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 perturbed anisotropic network model and molecular dynamics simulations applied, essential dynamics sampling and cavity and pathway analysis, structural response of BtuC protein quantified in terms of X-shifts shown, transport model discussed Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + vitamin B12/out
-
 Escherichia coli ADP + phosphate + vitamin B12/in
-
 ?
ATP + H2O + vitamin B12/out nucleotide binding and release in the vitamin B12 importer BtuCD analyzed, perturbed elastic network calculations and biased molecular dynamics simulations applied, peristaltic forces suggested to exclude vitamin B12 from the transporter pore Escherichia coli ADP + phosphate + vitamin B12/in
-
 ?

Synonyms

Synonyms Comment Organism
BtuF
-
 Escherichia coli