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Literature summary for 7.6.2.4 extracted from

  • van Roermund, C.W.; Visser, W.F.; Ijlst, L.; Waterham, H.R.; Wanders, R.J.
    Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid ?-oxidation (2011), Biochim. Biophys. Acta, 1811, 148-152.
    View publication on PubMed
Search for more literature for 7.6.2.4

Protein Variants

Protein Variants Comment Organism
additional information the phenotype of the pxa1/pxa2 yeast deletion mutant, i.e. impaired growth on oleate containing medium and deficient oxidation of oleic acid, can partially be rescued by human ABCD1. Cells expressing ABCD1 rescue of beta-oxidation activity is best with C24:0 and C26:0 as substrates Homo sapiens
additional information the phenotype of the pxa1/pxa2 yeast deletion mutant, i.e. impaired growth on oleate containing medium and deficient oxidation of oleic acid, can partially be rescued by human ABCD2. Cells expressing ABCD2 rescue of beta-oxidation activity is best with C22:0 and different unsaturated very long-chain fatty acids including C24:6 and especially C22:6 as substrates Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoform ABCD2
-
Homo sapiens P33897 isoform ABCD1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information best substrates for rescue of a yeast pxa1/pxa2 deletion mutant by ABCD1 are C22:0 and different unsaturated very long-chain fatty acids including C24:6 and especially C22:6 Homo sapiens ?
-
 ?
additional information best substrates for rescue of a yeast pxa1/pxa2 deletion mutant by ABCD1 are C24:0 and C26:0 fatty acids Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ABCD2
-
 Homo sapiens
ALDRP
-
 Homo sapiens