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Literature summary for 7.4.2.7 extracted from
- Mutations affecting phosphorylation, ubiquitination and turnover of the ABC-transporter Ste6 (2002), FEBS Lett., 531, 548-552.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| DELTA-Abox | concurrent loss of phosphorylation and ubiquitination in the A-box mutant | Saccharomyces cerevisiae |
| S623L | 3fold increased stability compared to wild-type enzyme, phosphorylation is reduced | Saccharomyces cerevisiae |
| T613A | 2fold increased stability compared to wild-type enzyme, phosphorylation is not affected | Saccharomyces cerevisiae |
| T613A/S623L | 5fold increased stability compared to wild-type enzyme | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
MATa his3-DELTA200 leu2-3,112 lys2-801 DELTAste6::LEU2 trp1-DELTA63 ura3-52 | - |
| Saccharomyces cerevisiae RKY959 | - |
MATa his3-DELTA200 leu2-3,112 lys2-801 DELTAste6::LEU2 trp1-DELTA63 ura3-52 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | Ste6 is phosphorylated in vivo, this phosphorylation is dependent on the presence of an acidic stretch (A-box) in the linker region shown to be important for ubiquitination and fast turnover of Ste6 | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ste6 | - |
Saccharomyces cerevisiae |
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