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Literature summary for 7.4.2.5 extracted from

  • Perria, C.L.; Rajamanickam, V.; Lapinski, P.E.; Raghavan, M.
    Catalytic site modifications of TAP1 and TAP2 and their functional consequences (2006), J. Biol. Chem., 281, 39839-39851.
    View publication on PubMed
Search for more literature for 7.4.2.5

Cloned(Commentary)

Cloned (Comment) Organism
baculoviruses encoding a histidine-tagged and a green fluorescent protein tagged version of TAP1, and a yellow fluorescent protein-tagged version of TAP2 are obtained Homo sapiens

Protein Variants

Protein Variants Comment Organism
D668E/Q701H TAP1 mutant Homo sapiens
D668N TAP1 mutant Homo sapiens
D668N/Q701A TAP1 mutant Homo sapiens
E632D TAP2 mutant Homo sapiens
E632D/H661Q TAP2 mutant Homo sapiens
E632Q TAP2 mutant Homo sapiens
E632Q/H661A TAP2 mutant Homo sapiens
E632Q/H662A TAP2 mutant Homo sapiens
H661Q TAP2 mutant Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane
-
 Homo sapiens 5789
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + peptide/in Homo sapiens
-
 ADP + phosphate + peptide/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + peptide/in
-
 Homo sapiens ADP + phosphate + peptide/out
-
 ?

Subunits

Subunits Comment Organism
heterodimer TAP1, TAP2 Homo sapiens

Synonyms

Synonyms Comment Organism
peptide-transporting ATPase
-
 Homo sapiens
TAP
-
 Homo sapiens