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Literature summary for 7.4.2.5 extracted from

  • Gorbulev, S.; Abele, R.; Tampe, R.
    Allosteric crosstalk between peptide-binding, transport, and ATP hydrolysis of the ABC transporter TAP (2001), Proc. Natl. Acad. Sci. USA, 98, 3732-3737.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.4.2.5

Inhibitors

Inhibitors Comment Organism Structure
ICP47 herpes simplex virus protein Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000161
-
 RRYQKSTEL pH 7.4, 32°C Homo sapiens
0.000574
-
 RRYNASTEL pH 7.4, 32°C Homo sapiens
0.3
-
 ATP pH 7.4, 32°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens ATPase activity associated with transporter associated with antigen processing, TAP. Role of TAP in peptide loading of MHC molecules and the overall process of antigen presentation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 ATPase activity associated with transporter associated with antigen processing, TAP
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphoma cell Burkitt lymphoma cell, i.e. Raji cell Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.93
-
 pH 7.4, 32°C, substrate RRYNASTEL Homo sapiens
2.02
-
 pH 7.4, 32°C, substrate RRYQKSTEL Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + EPGNTWDED/out
-
 Homo sapiens ADP + phosphate + EPGNTWDED/in
-
 ?
ATP + H2O + protein/out
-
 Homo sapiens ADP + phosphate + protein/in
-
 ?
ATP + H2O + RRYNASTEL/out
-
 Homo sapiens ADP + phosphate + RRYNASTEL/in
-
 ?
ATP + H2O + RRYQKSTEL/out
-
 Homo sapiens ADP + phosphate + RRYQKSTEL/in
-
 ?
additional information ATPase activity associated with transporter associated with antigen processing, TAP. Role of TAP in peptide loading of MHC molecules and the overall process of antigen presentation Homo sapiens ?
-
 ?
additional information coordinated dialogue between peptide binding site, nucleotide-binding domain, and the translocation site Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5
-
 ATP pH 7.4, 32°C Homo sapiens