Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Mdj2 | stimulates ATPase activity of mtHsp70 to the same extent as TIM14, forms a complex with TIM16, which does not interfer with the TIM16-TIM14 complex and cannot support cell growth, but overexpression of Mdj2 fully restores growth of cells lacking TIM14 | Saccharomyces cerevisiae | |
TIM14 | stimulates ATPase activity of mtHsp70 and thereby enables efficient binding of mtHsp70 to incoming preproteins, stimulates to the same extent as Mdj2, forms a complex with TIM16, which recruits it to the translocase, the TIM16-TIM14 complex does not interfer with the TIM16-Mdj2 complex | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
strains YPH499 and YPH501 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Saccharomyces cerevisiae | ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mtHSP70 | - |
Saccharomyces cerevisiae |