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Literature summary for 7.3.2.1 extracted from

  • Byskov, K.; Jensen, N.; Kongsfelt, I.; Wielsoe, M.; Pedersen, L.; Haldrup, C.; Pedersen, L.
    Regulation of cell proliferation and cell density by the inorganic phosphate transporter PiT1 (2012), Cell Div., 7, 7.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.3.2.1

Protein Variants

Protein Variants Comment Organism
additional information downregulation of PiT1 in two transformed human cells lines, HepG2 and HeLa, phenotypes, overview. Overexpression of hPiT1 or hPiT2 in MC3T3-E1 cells, phgenotypes, overview. Transduction study analyzing the presence of functional hPiT1, hPiT2, and mPiT2 on the cell surface of MC3T3-E1-LXSN, -LPiT1SN, -LPiT2SN, NIH3T3-LXSN, and -LPiT1SN cells Homo sapiens
additional information generation of PiT1 knock-out mice and isolated mouse embryonic fibroblasts with PiT1 knockout Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8WUM9
-
-
Mus musculus Q61609
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
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MC3T3-E1 cell endogenous PiT1 mRNA level is decreased in dense MC3T3-E1 cell cultures Mus musculus
-
NIH-3T3 cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
inorganic phosphate transporter
-
 Homo sapiens
inorganic phosphate transporter
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 Mus musculus
Pit1
-
 Homo sapiens
Pit1
-
 Mus musculus
Pit2
-
 Mus musculus
SLC20A1
-
 Homo sapiens
SLC20A1
-
 Mus musculus
type III Pi transporter
-
 Homo sapiens
type III Pi transporter
-
 Mus musculus

General Information

General Information Comment Organism
malfunction downregulation of PiT1 severely impairs the proliferation of two transformed human cells lines, HepG2 and HeLa, and the tumorigenicity of HeLa cells in nude mice. An increased PiT1 expression can indeed make NIH3T3 cells more sensitive to transformation. Phenotypes of MC3T3-E1 cells overexpressing hPiT1 or hPiT2, overview Homo sapiens
malfunction PiT1 knock-out mice do not survive past E12.5 and from E10.5, the embryos are growth-retarded and show reduced proliferation of liver cells. Isolated mouse embryonic fibroblasts MC3T3-E1 with knocked out as well as reduced PiT1 expression levels also exhibit impaired proliferation Mus musculus
physiological function a certain level of PiT1 is important for proliferation, role of PiT1 in regulation of cell proliferation, overview Homo sapiens
physiological function a certain level of PiT1 is important for proliferation, role of PiT1 in regulation of cell proliferation, overview Mus musculus