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Literature summary for 7.3.2.1 extracted from

  • Iharada, M.; Miyaji, T.; Fujimoto, T.; Hiasa, M.; Anzai, N.; Omote, H.; Moriyama, Y.
    Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter (2010), J. Biol. Chem., 285, 26107-26113.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.3.2.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed using the baculoviruses expression system Mus musculus

Protein Variants

Protein Variants Comment Organism
R138A mutant possesses Na+/phosphate cotransport activity comparable to that of the wild type protein, but the DELTA PSI-dependent anion transport is inactive Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3
-
 phosphate Vmax: 134 nmol/min/mg protein, pH 7, 27°C Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + phosphate/out
-
 Mus musculus ADP + phosphate + phosphate/in
-
 ?

Synonyms

Synonyms Comment Organism
NPT1
-
 Mus musculus
SLC17A1
-
 Mus musculus
type 1 sodium-dependent phosphate transporter (SLC17A1 protein)
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
27
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Mus musculus

General Information

General Information Comment Organism
physiological function NPT1 is a polyspecific anion transporter. Proteoliposomes containing purified SLC17A1 transport various organic anions such as p-aminohippuric acid, acetylsalicylic acid and urate in an inside positive membrane potential (DELTA PSI-dependent manner) Mus musculus