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Literature summary for 7.3.2.1 extracted from
- Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport (2010), J. Biol. Chem., 285, 25134-25138.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| apical plasma membrane | - |
Homo sapiens | 16324 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) interacts with C-terminal end of sodium-dependent phosphate transporter 2a | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) interacts with C-terminal end of sodium-dependent phosphate transporter 2a | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Npt2a | - |
Homo sapiens |
| sodium-dependent phosphate transporter 2a | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | phosphorylation of the sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) plays a key role in the regulation of renal phosphate transport by parathyroid hormone and dopamine. The substitution of serine for aspartic acid (S77D) in the PDZ I domain of NHERF-1 decreases the binding affinity to Npt2a | Homo sapiens |
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Release 2023.1 (January 2023)
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