Cloned (Comment) | Organism |
---|---|
gene ATP7A, genetic mapping and expression analysis of splicing variants, overview | Homo sapiens |
gene ATP7A, genetic mapping and expression analysis of splicing variants, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | 97 kDa variant | Homo sapiens | 5829 | - |
cytosol | 97 kDa variant | Rattus norvegicus | 5829 | - |
additional information | immunohistochemic localization analysis, overview | Homo sapiens | - |
- |
additional information | immunohistochemic localization analysis, overview | Rattus norvegicus | - |
- |
nucleus | 64 kDa variant | Homo sapiens | 5634 | - |
nucleus | 64 kDa variant | Rattus norvegicus | 5634 | - |
plasma membrane | 97 kDa variant | Homo sapiens | 5886 | - |
plasma membrane | 97 kDa variant | Rattus norvegicus | 5886 | - |
trans-Golgi network | - |
Homo sapiens | 5802 | - |
trans-Golgi network | - |
Rattus norvegicus | 5802 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens | |
Mg2+ | required | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
64000 | - |
x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Homo sapiens |
64000 | - |
x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Rattus norvegicus |
97000 | - |
x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Homo sapiens |
97000 | - |
x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | Homo sapiens | - |
ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | Rattus norvegicus | - |
ADP + phosphate + Cu2+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene ATP7A | - |
Rattus norvegicus | - |
gene ATP7A, three splicing variants | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
IEC-6 cell | - |
Rattus norvegicus | - |
intestinal epithelium | - |
Homo sapiens | - |
intestinal epithelium | - |
Rattus norvegicus | - |
intestine | - |
Homo sapiens | - |
intestine | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | - |
Homo sapiens | ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | - |
Rattus norvegicus | ADP + phosphate + Cu2+/out | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Homo sapiens |
? | x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
ATP7A | - |
Homo sapiens |
ATP7A | - |
Rattus norvegicus |
copper ATPase | - |
Homo sapiens |
copper ATPase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | iron deprivation induces all three splicing variants 5-7fold | up |
Rattus norvegicus | iron deprivation induces all three splicing variants 5-7fold | up |
General Information | Comment | Organism |
---|---|---|
metabolism | gene regulation of ATP7A by iron deprivation | Homo sapiens |
metabolism | gene regulation of ATP7A by iron deprivation | Rattus norvegicus |
additional information | mutation of ATP7A is involved in Menkes disease, a severe infantile-onset neurodegenerative disorder | Homo sapiens |
additional information | mutation of ATP7A is involved in Menkes disease, a severe infantile-onset neurodegenerative disorder | Rattus norvegicus |