Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi trans face | copper excess shown to provoke massive download of ATP7B retained in the Golgi network into the bile canalicular membrane | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | Homo sapiens | - |
ADP + phosphate + Cu2+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P35670 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bile canaliculus | cellular distribution of ATP7B, stable ATP7B pool localized to the tight junctions that seal the bile canaliculi shown | Homo sapiens | - |
liver | copper excretion into the bile | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
microscopy and cell fractionation studies applied to study cellular distribution of ATP7B, profile of radio-labelled copper excretion into the bile measured, evidence of copper excretion by transcytosis across the hepatocyte and by paracellular transport throughout the tight junctions discussed | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | - |
Homo sapiens | ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | correspondence between the site of ATP7B action and distribution and the pathways of copper disposal by the liver | Homo sapiens | ADP + phosphate + Cu2+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP7B | - |
Homo sapiens |