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Literature summary for 7.2.2.9 extracted from

  • Voskoboinik, I.; Mar, J.; Camakaris, J.
    Mutational analysis of the Menkes copper P-type ATPase (ATP7A) (2003), Biochem. Biophys. Res. Commun., 301, 488-494.
    View publication on PubMed
Search for more literature for 7.2.2.9

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild type and several mutants in Saccharomyces cerevisiae and CHO cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D1230A retains 21% of the activity compared to wild type Homo sapiens
DD1219/1220AA retains 80% of the activity compared to wild type Homo sapiens
H1086Q retains 20% of the activity compared to wild type Homo sapiens
K1097A retains 91% of the activity compared to wild type Homo sapiens
K1233M retains 17% of the activity compared to wild type Homo sapiens
N1366A inactive Homo sapiens
R1208G retains the activity of the wild type Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0009
-
 ATP D1230A mutant, pH 6.8, 37°C Homo sapiens
0.004
-
 ATP DD1219/1220AA mutant, pH 6.8, 37°C Homo sapiens
0.009
-
 ATP R1208G mutant, pH 6.8, 37°C Homo sapiens
0.016
-
 ATP wild type, pH 6.8, 37°C Homo sapiens
0.024
-
 ATP K1097A mutant, pH 6.8, 37°C Homo sapiens
0.15
-
 ATP K1233M mutant, pH 6.8, 37°C Homo sapiens
2.02
-
 ATP H1086Q mutant, pH 6.8, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 r

Synonyms

Synonyms Comment Organism
ATP7A
-
 Homo sapiens
Menkes copper P-type ATPase
-
 Homo sapiens
Menkes protein
-
 Homo sapiens
MNK
-
 Homo sapiens