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Literature summary for 7.2.2.8 extracted from

  • Ha, J.H.; Doguer, C.; Collins, J.F.
    Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells (2016), Metallomics, 8, 963-972 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q04656
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Rattus norvegicus D1MCF1
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Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
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 Homo sapiens
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IEC-6 cell
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 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
ATP7A
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 Homo sapiens
ATP7A
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 Rattus norvegicus

General Information

General Information Comment Organism
physiological function Fe uptake and efflux are impaired by Atp7a silencing Homo sapiens
physiological function Fe uptake and efflux are impaired by Atp7a silencing. Expression of the iron importer Dmt1, apical membrane ferrireductase Dcytb and iron exporter Fpn1 are decreased in Atp7a knockdown cells. Cell-surface ferrireductase activity increases about 5fold in Atp7a knockdown cells despite decreased Dcytb mRNA expression. Increased expression of iron oxidase hephaestin is associated with increased ferroxidase activity in knockdown cells Rattus norvegicus