Literature summary for 7.2.2.3 extracted from

Omotayo, T.I; Akinyemi, G.S.; Omololu, P.A.; Ajayi, B.O.; Akindahunsi, A.A.; Rocha, J.B.; Kade, I.J.
Possible involvement of membrane lipids peroxidation and oxidation of catalytically essential thiols of the cerebral transmembrane sodium pump as component mechanisms of iron-mediated oxidative stress-linked dysfunction of the pump's activity (2014), Redox Biol., 4, 234-241 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
Fe2+	dithiothreitol exerts considerable protective effect on the activity of the Fe2+-inhibited enzyme	Rattus norvegicus
malondialdehyde	-	Rattus norvegicus
additional information	not inhibited by vitamin E	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	transmembrane protein	Rattus norvegicus	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Na+[side 1]	Rattus norvegicus	-	ADP + phosphate + Na+[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebrum	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + K+[side 1]	-	Rattus norvegicus	ADP + phosphate + K+[side 2]	-	?
ATP + H2O + Na+[side 1]	-	Rattus norvegicus	ADP + phosphate + Na+[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
Na+/K+-ATPase	-	Rattus norvegicus
sodium pump	-	Rattus norvegicus

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Release 2023.1 (January 2023)