Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-(+)-[(2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid | a K+-Cl- cotransport, KCC, inhibitor, inhibits the enzyme in intact apical canalicular membranes, not in lealy membranes, via inhibition of the K+-Cl- cotransport | Homo sapiens | |
2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | i.e. SCH28080 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in + K+/out | Homo sapiens | K+-Cl- cotransporter KCC4 and H+,K+-ATPase are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell, overview | ADP + phosphate + H+/out + K+/in | - |
? | |
additional information | Homo sapiens | the K+-Cl- cotransport by KCC4 is tightly coupled with H+/K+ antiport by H+,K+-ATPase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
oxyntic cell | stimulation-associated vesicles of apical canalicular membrane | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in + K+/out | - |
Homo sapiens | ADP + phosphate + H+/out + K+/in | - |
? | |
ATP + H2O + H+/in + K+/out | K+-Cl- cotransporter KCC4 and H+,K+-ATPase are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell, overview | Homo sapiens | ADP + phosphate + H+/out + K+/in | - |
? | |
additional information | the K+-Cl- cotransport by KCC4 is tightly coupled with H+/K+ antiport by H+,K+-ATPase | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H+K+-ATPase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |