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Literature summary for 7.2.2.14 extracted from

  • Hirata, Y.; Funato, Y.; Miki, H.
    Basolateral sorting of the Mg2+ transporter CNNM4 requires interaction with AP-1A and AP-1B (2014), Biochem. Biophys. Res. Commun., 455, 184-189.
    View publication on PubMed
Search for more literature for 7.2.2.14

Protein Variants

Protein Variants Comment Organism
L323A/L324A mutation in potential basolateral sorting signal, does not affect basolateral localization of isoform CNNM4 Homo sapiens
L550A/L551A/L552A mutation in potential basolateral sorting signal, does not affect basolateral localization of isoform CNNM4 Homo sapiens
L575A/L576A mutation in potential basolateral sorting signal, mutant protein is expressed on both apical and basolateral surfaces in approximately half of the observed cells Homo sapiens
L575A/L576A/L758A/L759A/L765A/L766A mutation in potential basolateral sorting signals, mutant protein is found on both apical and basolateral surfaces in almost all of the observed cells. Mutation disrupts interaction with my1A and my1B Homo sapiens
L578A/L579A mutation in potential basolateral sorting signal, mutant vprotein is observed throughout the cytoplasm Homo sapiens
L758A/L759A mutation in potential basolateral sorting signal, mutant protein is expressed on both apical and basolateral surfaces in approximately half of the observed cells Homo sapiens
L765A/L766A mutation in potential basolateral sorting signal, mutant protein is expressed on both apical and basolateral surfaces in approximately half of the observed cells Homo sapiens
Y351A mutation in potential basolateral sorting signal, does not affect basolateral localization of isoform CNNM4 Homo sapiens
Y405A mutation in potential basolateral sorting signal, does not affect basolateral localization of isoform CNNM4 Homo sapiens
Y488A mutation in potential basolateral sorting signal, does not affect basolateral localization of isoform CNNM4 Homo sapiens
Y581A mutation in potential basolateral sorting signal, does not affect basolateral localization of isoform CNNM4 Homo sapiens
Y708A mutation in potential basolateral sorting signal, mutant vprotein is observed throughout the cytoplasm Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane basolateral localization of both endogenous and ectopically expressed transporter CNNM4. Single knockdown of my1B, a cargo-recognition subunit of AP-1B, does not affect basolateral localization, but simultaneous knockdown of the my1A subunit of AP-1A abrogates localization Homo sapiens 16020
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q6P4Q7
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Source Tissue

Source Tissue Comment Organism Textmining
kidney Madin-Darby kidney cell, basolateral localization of both endogenous and ectopically expressed transporter CNNM4. Single knockdown of my1B, a cargo-recognition subunit of AP-1B, does not affect basolateral localization, but simultaneous knockdown of the my1A subunit of AP-1A abrogates localization Homo sapiens
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Synonyms

Synonyms Comment Organism
CNNM4
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 Homo sapiens